|
rs11208659
|
|
C |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
|
23563609 |
2013 |
|
rs11208659
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
|
23563609 |
2013 |
|
rs193922650
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity.
|
15972940 |
2005 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched electronic databases, including population-based studies that investigated the association between LEPR variants Q223R, K109R and K656N and obesity- related phenotypes in healthy, unrelated subjects.
|
22028824 |
2011 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in leptin gene LEP (A19G and G2548A) and leptin receptor gene LEPR (K109R and Q223R) and their association with fasting plasma leptin level (PLL) and obesity in a Malaysian suburban population in Kampar, Perak.
|
24947733 |
2014 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Allele dosage analysis of rs2069845, rs1137100, and rs3801266 revealed that children with five to six risk alleles had an approximately four times increased risk of obesity than children with less than two risk alleles (P = 1.2 × 10(-7)).
|
22228719 |
2012 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings support the hypothesis that the Q223R polymorphism (but not the K109R or K656N polymorphism) of the leptin receptor gene is associated with obesity and predicts a small percentage of body weight and body composition variability in a genetically homogeneous population.
|
11549688 |
2001 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity.
|
20183928 |
2010 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The K109R polymorphism was associated with obesity (P = .025) and seems to significantly decrease the LEP levels (P < .001).
|
29893028 |
2018 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that c.517A→G and Lys(109)Arg contribute to the variation in anthropometric obesity phenotype indicators observed among Black African and mixed-ancestry South African learners.
|
21921635 |
2011 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, our data suggest that a combination of polymorphism in the LEP gene 3' flanking region, and Lys109Arg, Lys656Asn variants in LEPR gene is associated with obesity in Chinese Han population.
|
24308887 |
2013 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study evaluated the association between obesity and the K109R, Q223R, and K656N polymorphisms of the leptin receptor (LEPR) locus.
|
22746211 |
2012 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The haplotype combination of LEP c.-2548G>A and LEPR p.Q223R</span> variants was related to a 58% increase in obesity risk.
|
18273796 |
2007 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Obesity-related genetic factors including common polymorphisms in the leptin gene (LEP A19G and G-2548A) and its receptor (LEPR Q223R) were investigated in DNA available for 376 patients and 805 controls.
|
15159310 |
2004 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We obtained higher serum leptin levels in infants with the GG genotype for Lepr A668G, with haplotype GG/GG for Lep G2548A/A19G, and with GG/GG-GG (LepG2548A/A19G-Lepr A668G); thus, it seems that the genotype GG could be a protector against obesity development in infancy and adulthood.
|
28628399 |
2017 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results indicate that LEP G-2548A and LEPR Q223R SNPs may not be considered as genetic risk factors for obesity in a sample of Romanian population.
|
19913498 |
2010 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in leptin gene LEP (A19G and G2548A) and leptin receptor gene LEPR (K109R and Q223R) and their association with fasting plasma leptin level (PLL) and obesity in a Malaysian suburban population in Kampar, Perak.
|
24947733 |
2014 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings support the hypothesis that the Q223R polymorphism (but not the K109R or K656N polymorphism) of the leptin receptor gene is associated with obesity and predicts a small percentage of body weight and body composition variability in a genetically homogeneous population.
|
11549688 |
2001 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphisms in leptin (LEP G-2548A) and leptin-receptor (LEPR Gln223Arg) seem to influence obesity and lipid metabolism among others.
|
26064921 |
2015 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to assess the impact of mothers' and newborns' fat mass and obesity-associated gene (FTO) rs9939609 and leptin receptor (LEPR) rs1137101 gene polymorphisms on neonatal anthropometric parameters in order to identify a potential risk for developing obesity.We performed a cross-sectional study on 355 mother-newborn couples in an Obstetrics Gynecology Tertiary Hospital from Romania, evaluated with regard to anthropometric parameters, clinical and laboratory parameters besides 2 genetic polymorphisms (FTO rs9939609 and LEPR rs1137101).Newborns with mothers carrying variant AT or AA genotype for FTO rs9939609 presented lower BMI (P = 0.012) and lower MUAC (P = 0.029).
|
27930556 |
2016 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between overweight/obesity and polymorphisms in the LEP (rs7799039), LEP receptor (LEPR; rs1137101), and ADIPOQ genes (rs2241766, rs1501299) with the response to breast cancer treatment in Mexican women.
|
28416193 |
2017 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Similarly, LEPR 668 A/G + G/G carriers with a high fat total intake had 3.0 times higher risk of obesity (p = 0.002) and 4.1 times higher risk of hypercholesterolemia (p = 0.001).
|
26365669 |
2015 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we hypothesized that the LEP-rs7799039 and LEPR-rs1137101 SNPs are related to the risk of pre-pregnancy overweight/obesity (body mass index ≥25 kg/m<sup>2</sup>) as well as to excessive gestational weight gain (GWG) and high concentrations of leptin throughout pregnancy.
|
29241578 |
2017 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, the present study aimed to evaluate the relationships among the gene polymorphisms ghrelin (GHRL-rs26802), ghrelin receptor (GHSR-rs572169), leptin (LEP-rs7799039), leptin receptor (LEPR-rs1137101) and fat mass and obesity-associated (FTO-rs9939609) and obesity.
|
26255942 |
2015 |