|
rs1799750
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<b>Conclusion.</b> We systematically investigated the association between MMP-1-1607 (rs1799750) 1G/2G polymorphism and OA susceptibility; however, the results show no correlation.
|
30886066 |
2019 |
|
rs143383
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As GDF5 codes for a cartilage anabolic protein, this reduced expression may explain why the T-allele of rs143383 is an OA risk factor.
|
22929025 |
2013 |
|
rs143383
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs143383 and three highly correlated single nucleotide polymorphisms (SNPs) in the GDF5 region were found to be independently associated with OA, height, bone size and fracture risk in women.
|
19029166 |
2009 |
|
rs61752717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
M694V was the most frequent mutation (5%) in the osteoarthritis group, whereas in the control group, E148Q was the most common (16%).
|
24009456 |
2013 |
|
rs1143627
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).
|
19733643 |
2010 |
|
rs16944
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).
|
19733643 |
2010 |
|
rs419598
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).
|
19733643 |
2010 |
|
rs143383
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A compelling genetic association with osteoarthritis (OA) of a functional SNP (rs143383, T/C) in the 5'-UTR of the GDF5 gene was recently reported in case-control cohorts from Japan and China.
|
17616513 |
2007 |
|
rs143383
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional single nucleotide polymorphism (SNP) +104T/C in the 5'-UTR of GDF5 (rs143383) was reported to be associated with osteoarthritis susceptibility in Han Chinese and Japanese populations.
|
28886316 |
2017 |
|
rs143383
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional single nucleotide polymorphism (SNP) in the 5'-untranslated region of GDF5 (rs143383) was reported to be associated with osteoarthritis susceptibility.
|
18947434 |
2008 |
|
rs11965969
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A genetic association between the COL10A1 rs11965969 polymorphism and OA was also found.
|
20498197 |
2010 |
|
rs143383
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A genetic deficit mediated by SNP rs143383 that leads to reduced expression of GDF5 is strongly associated with large-joint osteoarthritis.
|
24466161 |
2014 |
|
rs12901404
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.
|
19508968 |
2009 |
|
rs6094710
|
|
A |
0.720 |
GeneticVariation |
GWASCAT |
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
|
23989986 |
2014 |
|
rs3757837
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
|
23989986 |
2014 |
|
rs41310883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A nonsynonymous single nucleotide variant rs41310883 (c.524C>T, p.Thr175Met) in TUFT1 gene was found to co-segregate perfectly with MTP I OA.
|
28410428 |
2017 |
|
rs3830675
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A strong positive correlation was found between PTEN rs3830675 polymorphism and OA risk, and this SNP was more frequent in the smokers and drinkers groups.
|
31704287 |
2019 |
|
rs10172410
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A variant in MCF2L is associated with osteoarthritis.
|
21871595 |
2011 |
|
rs62174901
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A variant in MCF2L is associated with osteoarthritis.
|
21871595 |
2011 |
|
rs62174906
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A variant in MCF2L is associated with osteoarthritis.
|
21871595 |
2011 |
|
rs1676486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AEI at rs1676486 is a risk factor for LDH, but not for OA.
|
23497244 |
2013 |
|
rs769389061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Aim of the current study was to estimate the link of resistin gene polymorphisms (- 420 C>G, + 299 G>A) with genetic susceptibility of knee OA in a Pakistani population.
|
30903575 |
2019 |
|
rs768876280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Aiming to delineate novel neuro-immune mechanisms for NGF/TrkA signalling in osteoarthritis (OA) pain, we evaluated inflammatory changes in the knee joints following injection of monoiodoacetate (MIA) in mice carrying a TrkA receptor mutation (P782S; TrkA KI mice).
|
28844566 |
2018 |
|
rs3743930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the number of patients studied was insufficient to claim that E148Q gene mutation protects against osteoarthritis, the potential of this gene merits further investigation.
|
24009456 |
2013 |
|
rs288326
|
|
|
0.030 |
GeneticVariation |
BEFREE |
An association analysis of 2 variants (R200W and R324G) of FRZB was performed in a random sample of 1,369 subjects (ages 55-70 years) from a population-based cohort (the Rotterdam Study) scored for radiographic characteristics of OA in the hip, hand, spine, and knee and in a patient population of Caucasian probands (ages 40-70 years) and their siblings selected for the presence of primary symptomatic OA at multiple sites.
|
15818669 |
2005 |