Gene: TCF4 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9960767
rs9960767
TCF4
C 0.880 GeneticVariation GWASDB Common variants conferring risk of schizophrenia. 19571808

2009
dbSNP: rs9960767
rs9960767
TCF4
C 0.880 GeneticVariation GWASCAT Common variants conferring risk of schizophrenia. 19571808

2009
dbSNP: rs17594526
rs17594526
TCF4
T 0.800 GeneticVariation GWASDB Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. 19571811

2009
dbSNP: rs17594526
rs17594526
TCF4
T 0.800 GeneticVariation GWASCAT Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. 19571811

2009
dbSNP: rs9960767
rs9960767
TCF4
0.880 GeneticVariation BEFREE Thus, we hypothesized that the disease-associated C allele of the rs9960767 polymorphism of the TCF4 gene led to impaired VDM functioning in schizophrenia patients. 21228604

2011
dbSNP: rs9960767
rs9960767
TCF4
0.880 GeneticVariation BEFREE We therefore investigated the impact of the schizophrenia susceptibility gene TCF4 (rs9960767) on sensorimotor gating of the ASR in healthy humans and in patients with a schizophrenia spectrum disorder. 21543597

2011
dbSNP: rs9960767
rs9960767
TCF4
0.880 GeneticVariation GWASDB Common variants at VRK2 and TCF4 conferring risk of schizophrenia. 21791550

2011
dbSNP: rs17512836
rs17512836
TCF4
C 0.810 GeneticVariation GWASDB Genome-wide association study identifies five new schizophrenia loci. 21926974

2011
dbSNP: rs17512836
rs17512836
TCF4
C 0.810 GeneticVariation GWASCAT Genome-wide association study identifies five new schizophrenia loci. 21926974

2011
dbSNP: rs9960767
rs9960767
TCF4
0.880 GeneticVariation BEFREE As measured by prepulse inhibition, the schizophrenia risk allele C of TCF4 rs9960767 reduces sensorimotor gating. 21932083

2011
dbSNP: rs9960767
rs9960767
TCF4
0.880 GeneticVariation BEFREE P50 suppression was significantly decreased in carriers of schizophrenia risk alleles of the TCF4 polymorphisms rs9960767, rs10401120rs, rs17597926, and 17512836 (P < 0.0002-0.00005). 22451930

2012
dbSNP: rs17597926
rs17597926
TCF4
0.700 GeneticVariation GWASCAT Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. 22688191

2012
dbSNP: rs2958182
rs2958182
TCF4 ; TCF4-AS1
0.020 GeneticVariation BEFREE The SNP rs2958182 was reported to be significantly associated with schizophrenia (SCZ) in Han Chinese. 23249814

2013
dbSNP: rs11152369
rs11152369
TCF4
A 0.700 GeneticVariation GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885

2013
dbSNP: rs1261117
rs1261117
TCF4
T 0.800 GeneticVariation GWASDB A comprehensive family-based replication study of schizophrenia genes. 23894747

2013
dbSNP: rs1261117
rs1261117
TCF4
T 0.800 GeneticVariation GWASCAT A comprehensive family-based replication study of schizophrenia genes. 23894747

2013
dbSNP: rs9960767
rs9960767
TCF4
0.880 GeneticVariation BEFREE Single nucleotide polymorphisms in TCF4 gene have been consistently associated with schizophrenia in genome wide association studies, including the C allele of rs9960767. 24275585

2014
dbSNP: rs9960767
rs9960767
TCF4
0.880 GeneticVariation BEFREE The analyses on the 28 individual SNPs previously associated with schizophrenia found that two SNPs in TCF4 returned a significant association with the SPEQ Paranoia dimension, rs17512836 (p-value = 2.57×10⁻⁴) and rs9960767 (p-value = 6.23×10⁻⁴). 24718684

2014
dbSNP: rs17512836
rs17512836
TCF4
0.810 GeneticVariation BEFREE The analyses on the 28 individual SNPs previously associated with schizophrenia found that two SNPs in TCF4 returned a significant association with the SPEQ Paranoia dimension, rs17512836 (p-value = 2.57×10⁻⁴) and rs9960767 (p-value = 6.23×10⁻⁴). 24718684

2014
dbSNP: rs9636107
rs9636107
TCF4
G 0.700 GeneticVariation GWASCAT Biological insights from 108 schizophrenia-associated genetic loci. 25056061

2014
dbSNP: rs9636107
rs9636107
TCF4
G 0.700 GeneticVariation GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764

2015
dbSNP: rs2958182
rs2958182
TCF4 ; TCF4-AS1
0.020 GeneticVariation BEFREE This study found that the A allele of the TCF4 rs2958182 polymorphism was the risk allele of schizophrenia, and was associated with lower cognitive performance in language in schizophrenia and delayed memory in controls. 26343600

2015
dbSNP: rs1452787
rs1452787
TCF4
0.010 GeneticVariation BEFREE Further interaction and stratification analysis suggested that rs1452787 was notably correlated with increased SCZ risk in males (OR = 2.77, 95%CI = 1.43-5.35, P = 0.002). 27103199

2016
dbSNP: rs7235757
rs7235757
TCF4
0.010 GeneticVariation BEFREE We found that the genotype "AG" of rs9320010 and "GA" of rs7235757 decreased SCZ risk (OR = 0.70, 95%</span>CI = 0.50-0.99, P = 0.041; OR = 0.69, 95%CI = 0.49-0.97, P = 0.034, respectively). 27103199

2016
dbSNP: rs9320010
rs9320010
TCF4
0.010 GeneticVariation BEFREE We found that the genotype "AG" of rs9320010 and "GA" of rs7235757 decreased SCZ</span> risk (OR = 0.70, 95%CI = 0.50-0.99, P = 0.041; OR = 0.69, 95%CI = 0.49-0.97, P = 0.034, respectively). 27103199

2016