|
rs764901021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The two adjacent polymorphisms displayed a nominally significant association with schizophrenia (IVS2+ 1587G>A, p = .014; 396T<A or Asp123Glu, p = .024).
|
15522253 |
2004 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These convergent data suggest that allelic variation within DISC1, either at Ser704Cys or haplotypes monitored by it, increases the risk for schizophrenia and that the mechanism of this effect involves structural and functional alterations in the hippocampal formation.
|
15939883 |
2005 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A three-SNP haplotype [hCV219779 (C)-rs821597 (G)-rs821616 (A)] spanning 83 kb of the gene was associated with schizophrenia in a family-based sample (P = 0.002).
|
15939883 |
2005 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The strongest association is with a haplotype of SNPs rs751229 and rs3738401, located at the 5' end of the gene; the C-A haplotype of these SNPs is associated with a relative risk of schizophrenia of 5 in our population.
|
16389590 |
2006 |
|
rs751229
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest association is with a haplotype of SNPs rs751229 and rs3738401, located at the 5' end of the gene; the C-A haplotype of these SNPs is associated with a relative risk of schizophrenia of 5 in our population.
|
16389590 |
2006 |
|
rs1238276682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the NIMH sibling study (SS), a non-independent case-control set, and an independent German (G) case-control set, we performed conditional/unconditional logistic regression to test for epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes.
|
17006672 |
2007 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We detected significant associations between a DISC1 haplotype containing Ser704Cys and Ser704Cys genotype and lifetime severity of delusions in SZ.
|
17054920 |
2007 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
When haplotypes were constructed with two, three, and four markers, a number of haplotype combinations, especially those including rs821616 and rs821597, were significantly associated with schizophrenia.
|
17286247 |
2007 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
When haplotypes were constructed with two, three, and four markers, a number of haplotype combinations, especially those including rs821616 and rs821597, were significantly associated with schi</span>zophrenia.
|
17286247 |
2007 |
|
rs764901021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia.
|
17374448 |
2007 |
|
rs1322784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, evidence for association to Asperger syndrome was observed with an intragenic single nucleotide polymorphism (SNP) of DISC1 (rs1322784; P=0.0058), as well as with a three-SNP haplotype (P=0.0013) overlapping the HEP3 haplotype, that was previously observed to associate with schizophrenia in Finnish families.
|
17579608 |
2008 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In further endophenotype stratification, however, we found a significant association between rs821616 and the poor concentration subgroup of SCZ, determined using the Operational Criteria Checklist (codominant model, p=0.015).
|
17997036 |
2008 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To examine any association between DISC1 and SCZ, we genotyped three clinical single nucleotide polymorphisms (SNPs) (rs3738401, R264Q; rs3738402, L465L; rs821616, S704C) in the coding region of the DISC1 gene using the Illumina Sentrix Array Matrix chip and direct sequencing in 303 patients with SCZ and 300 healthy controls.
|
17997036 |
2008 |
|
rs3738402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine any association between DISC1 and SCZ, we genotyped three clinical single nucleotide polymorphisms (SNPs) (rs3738401, R264Q; rs3738402, L465L; rs821616, S704C) in the coding region of the DISC1 gene using the Illumina Sentrix Array Matrix chip and direct sequencing in 303 patients with SCZ and 300 healthy controls.
|
17997036 |
2008 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated whether the DISC1 leu607phe polymorphism was associated with prefrontal gray matter volumes using magnetic resonance imaging in a cohort of patients with schizophrenia (N=19) and healthy volunteers (N=25) and positive and negative symptoms in 200 patients with schizophrenia.
|
18078707 |
2008 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, we confirm that two common structural variants (Q264R and S704C) elevate the risk for schizophrenia slightly (odds ratio 1.3, 95% CI: 1.0-1.7).
|
18164685 |
2008 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition, we confirm that two common structural variants (Q264R and S704C) elevate the risk for schizophrenia slightly (odds ratio 1.3, 95% CI: 1.0-1.7).
|
18164685 |
2008 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Secondary analyses revealed no direct relationship between NDE1 genotype and SZ; however, there was an opposite pattern of risk for NDE1 genotype when conditioned on DISC1 Ser704Cys, with NDE1 rs3784859 imparting a significant effect but only in the context of a Cys-carrying background.
|
18469341 |
2008 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common nonsynonymous single nucleotide polymorphism leading to a serine-to-cysteine substitution at amino acid 704 (Ser(704)Cys) in the DISC1 protein sequence has been recently associated with schizophrenia and with specific hippocampal abnormalities.
|
19046394 |
2008 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These different genotype effects of the DISC1 Ser704Cys polymorphism on the brain morphology in schizophrenia patients and healthy comparison subjects suggest that variation in the DISC1 gene might be, at least partly, involved in the neurobiology of schizophrenia.
|
19304459 |
2009 |
|
rs1538979
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirm the SNP interplay effect between rs1538979 and rs821633 that significantly conferred disease risk in male patients with schizophrenia (P = 0.016, OR 1.57).
|
19414483 |
2009 |
|
rs821633
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirm the SNP interplay effect between rs1538979 and rs821633 that significantly conferred disease risk in male patients with schizophrenia (P = 0.016, OR 1.57).
|
19414483 |
2009 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Schizophrenia risk-associated polymorphisms [non-synonymous SNPs rs821616 (Cys704Ser) and rs6675281 (Leu607Phe), and rs821597] were associated with the expression of Delta3 and Delta7Delta8.
|
19805229 |
2009 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Schizophrenia risk-associated polymorphisms [non-synonymous SNPs rs821616 (Cys704Ser) and rs6675281 (Leu607Phe), and rs821597] were associated with the expression of Delta3 and Delta7Delta8.
|
19805229 |
2009 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Schizophrenia risk-associated polymorphisms [non-synonymous SNPs rs821616 (Cys704Ser) and rs6675281 (Leu607Phe), and rs821597] were associated with the expression of Delta3 and Delta7Delta8.
|
19805229 |
2009 |