rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We tested rs401681 for association with 16 additional cancer types in over 30,000 cancer cases and 45,000 controls and found association with lung cancer (OR = 1.15, P = 7.2 x 10(-8)) and urinary bladder, prostate and cervix cancer (ORs = 1.07-1.31, all P < 4 x 10(-4)).
|
19151717 |
2009 |
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Consistent with published data, variant genotypes of 5p15 (rs402710), 6p21 and 15q25 showed dose-dependent associations with lung cancer risk.
|
19465454 |
2009 |
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
SNP rs31489 showed the strongest evidence of familial lung cancer association on 5p15.33 (P = 2 x 10(-4); odds ratio, 0.57; 95% confidence interval, 0.42-0.77), whereas rs3117582 showed a weak association on 6p21.33 (P = 0.09; odds ratio, 1.47; 95% confidence interval, 0.94-2.31).
|
20142248 |
2010 |
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest in adenocarcinoma and squamous cell carcinomas.
|
20548021 |
2010 |
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
The rs31489 variant on 5p15.33 is associated with bronchial obstruction, presence and severity of emphysema, and lung cancer.
|
21622582 |
2011 |
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, rs402710 (5p15.33), rs16969968 and rs8034191 (both 15q25.1) and rs4324798 (6p22.1) were found to be unrelated to survival times in this large cohort of lung cancer patients, regardless of whether the cause of death was from lung cancer or not.
|
21750227 |
2011 |
rs465498
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four independent SNPs (rs2736100, rs402710, rs4488809 and rs4083914), were found to be associated with a risk of lung cancer.
|
23228068 |
2012 |
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For lung cancer, which was the most studied tumor type, the estimated joint population attributable risk for three polymorphisms (TERT rs2736100, intergenic rs4635969, and CLPTM1L rs402710) was 41%.
|
22523397 |
2012 |
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The results from our case-control study and meta-analysis provide convincing evidence that rs401681 is significantly associated with lung cancer risk.
|
23653681 |
2013 |
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our findings provide further evidence supporting rs401681 as a genetic variant associated with the risk of lung cancer.
|
24386361 |
2013 |
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We genotyped rs2736100 (TERT) and rs401681 (CLPTM1L) SNPs in a case-control study with 399 lung cancer cases and 466 controls form Taiyuan, China.
|
23433592 |
2013 |
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results from our replication study and the meta-analysis provided firm evidence that rs402710 T allele significantly contributed to decreased lung cancer risk, and the case-control study implied that the variant may yield stronger effect on NSCLC and never smokers.
|
24194831 |
2013 |
rs31490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the logistic regression analysis, TERT-rs2853669, rs2736108, and CLPTM1L-rs31490 were significant associated with increased risk of lung cancer (OR = 1.46, 95% CI = 1.22-1.75; OR = 1.22, 95% CI = 1.00-1.49 and OR = 1.74, 95% CI = 1.35-2.23 under additive model, respectively).
|
23908149 |
2013 |
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
No association was found between CLPTM1L-rs401681 and lung cancer risk.
|
24861918 |
2014 |
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found rs402710 and rs401681 were associated with decreased lung cancer risk.
|
25526467 |
2014 |
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, our study indicated that the CLPTM1L - rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations.
|
24634236 |
2014 |
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our findings demonstrated that rs402710 and rs401681 are risk-conferring factors for the development of lung cancer.
|
24907075 |
2014 |
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.
|
25422207 |
2014 |
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.
|
24535780 |
2014 |
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant multiplicative interactions were observed between gender and polymorphisms of rs402710, the "T/T" genotype of which was associated with decreased lung cancer risk in male patients (p = 0.016, OR = 0.35, 95 % CI: 0.17-0.73).
|
25155038 |
2014 |
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that rs402710 and rs401681 are risk-conferring factors for the development of lung cancer.
|
24907075 |
2014 |