|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)).
|
26590902 |
2016 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After that, a number of studies reported that the rs2736100, rs401681, rs402710, and rs31489 polymorphisms at chromosome 5p15 have been implicated in LC risk.
|
24615522 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |
|
rs401681
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
|
18978787 |
2008 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Consistent with published data, variant genotypes of 5p15 (rs402710), 6p21 and 15q25 showed dose-dependent associations with lung cancer risk.
|
19465454 |
2009 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
GWASDB |
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
|
19654303 |
2009 |
|
rs465498
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395, were reported by genome wide association studies (GWASs) to be closely related to the susceptibility of lung cancer (LC), gastric cancer (GC) or esophageal cancer (EC) in Han population from northern or southern China.
|
26176862 |
2015 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For lung cancer, which was the most studied tumor type, the estimated joint population attributable risk for three polymorphisms (TERT rs2736100, intergenic rs4635969, and CLPTM1L rs402710) was 41%.
|
22523397 |
2012 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four independent SNPs (rs2736100, rs402710, rs4488809 and rs4083914), were found to be associated with a risk of lung cancer.
|
23228068 |
2012 |
|
rs380286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further stratification analysis showed that rs380286 displayed a significantly decreased lung cancer risk (OR=0.65, P=0.041) in the non-drinkers.
|
25526467 |
2014 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, rs402710 (5p15.33), rs16969968 and rs8034191 (both 15q25.1) and rs4324798 (6p22.1) were found to be unrelated to survival times in this large cohort of lung cancer patients, regardless of whether the cause of death was from lung cancer or not.
|
21750227 |
2011 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, in males, the TERT rs2736098 and CLPTM1L rs401681 T alleles are the susceptibility factors for developing lung cancer.
|
28789383 |
2017 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, our study indicated that the CLPTM1L - rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations.
|
24634236 |
2014 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.
|
24535780 |
2014 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found rs402710 and rs401681 were associated with decreased lung cancer risk.
|
25526467 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found rs402710 and rs401681 were associated with decreased lung cancer risk.
|
25526467 |
2014 |
|
rs31490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the logistic regression analysis, TERT-rs2853669, rs2736108, and CLPTM1L-rs31490 were significant associated with increased risk of lung cancer (OR = 1.46, 95% CI = 1.22-1.75; OR = 1.22, 95% CI = 1.00-1.49 and OR = 1.74, 95% CI = 1.35-2.23 under additive model, respectively).
|
23908149 |
2013 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
|
22899653 |
2012 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
GWASDB |
Lung cancer susceptibility locus at 5p15.33.
|
18978790 |
2008 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
No association was found between CLPTM1L-rs401681 and lung cancer risk.
|
24861918 |
2014 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that rs402710 and rs401681 are risk-conferring factors for the development of lung cancer.
|
24907075 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our findings demonstrated that rs402710 and rs401681 are risk-conferring factors for the development of lung cancer.
|
24907075 |
2014 |