Positive associations were also found between the polymorphisms rs2280090, rs2787094, rs44707 and rs528557</span> and childhood asthma in some genetic models.
The replication of the negative association of the CG/GG-genotype of rs528557 ADAM33 with childhood asthma in an independent birth cohort study confirms that a compromised ADAM33 gene may be implicated in the progression of wheeze into childhood asthma.