|
rs1045494
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five miRNA binding site SNPs associated significantly with breast cancer risk: rs1045494 (odds ratio (OR) 0.92; 95% confidence interval (CI): 0.88-0.96), rs1052532 (OR 0.97; 95% CI: 0.95-0.99), rs10719 (OR 0.97; 95% CI: 0.94-0.99), rs4687554 (OR 0.97; 95% CI: 0.95-0.99, and rs3134615 (OR 1.03; 95% CI: 1.01-1.05) located in the 3' UTR of CASP8, HDDC3, DROSHA, MUSTN1, and MYCL1, respectively.
|
25390939 |
2014 |
|
rs3817578
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a three-SNP haplotype across rs3834129, rs6723097, and rs3817578 that was significantly associated with breast cancer (P < 5 × 10(-6)), with a dominant risk ratio and 95% CI of 1.28 (1.21-1.35) and frequency of 0.29 in controls.
|
22056502 |
2012 |
|
rs6723097
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a three-SNP haplotype across rs3834129, rs6723097, and rs3817578 that was significantly associated with breast cancer (P < 5 × 10(-6)), with a dominant risk ratio and 95% CI of 1.28 (1.21-1.35) and frequency of 0.29 in controls.
|
22056502 |
2012 |
|
rs1044484322
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a significantly increased breast cancer</span> risk with increasing minor alleles for IL1A A114S (rs17561); heterozygote OR 1.2 (95% CI, 1.0-1.4) and homozygote OR 1.5 (95% CI, 1.1-2.0), P(trend) = 0.008.
|
17932347 |
2007 |
|
rs1221800282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For five SNPs--CASP8 D302H, IGFBP3 -202 c>a, PGR V660L, SOD2 V16A, and TGFB1 L10P--the associations with breast cancer were of borderline statistical significance (P = .016, .060, .047, .056, and .0088 respectively).
|
17018785 |
2006 |
|
rs34210251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For five SNPs--CASP8 D302H, IGFBP3 -202 c>a, PGR V660L, SOD2 V16A, and TGFB1 L10P--the associations with breast cancer were of borderline statistical significance (P = .016, .060, .047, .056, and .0088 respectively).
|
17018785 |
2006 |
|
rs10931936
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data showed a protective effect for CC genotype of rs1045485 variant and C-C haplotype of rs10931936-rs104548 in CASP8 in association with the decrease risk of breast cancer whereas rs10931936 showed no significant association.
|
31362911 |
2019 |
|
rs10931936
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.
|
22160591 |
2012 |
|
rs3834129
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our results indicate that genetic variations in the promoter region of CASP8 gene, especially rs3834129, may serve as a genetic risk factor for breast cancer in an Iranian population.
|
31257627 |
2019 |
|
rs3834129
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The minor allele of two caspase 8 polymorphisms, namely CASP8 -652 6N InsDel (rs3834129) and CASP8 Asp302His (rs1045485), were repeatedly associated with reduced breast cancer susceptibility.
|
27507139 |
2016 |
|
rs3834129
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Bi-directional PCR allele-specific amplification (bi-PASA) for detection of caspase-8 -652 6N ins/del promoter polymorphism (rs3834129) in breast cancer.
|
22659694 |
2012 |
|
rs3834129
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These results suggest that the minor allele del of rs3834129 is associated under a dominant model with increased breast cancer risk in carriers of BRCA1 mutations but not in carriers of BRCA2 mutations.
|
20652397 |
2011 |
|
rs3834129
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Polymorphisms in CASP8 at 2q33.1 have been associated with the risk of developing cancer, specifically, the D302H variant (rs1045485) with breast cancer in the European population and the -652 6N ins/del promoter variant (rs3834129) with multiple tumours including colorectal cancer (CRC) in the Chinese population.
|
18362937 |
2008 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer.
|
31467295 |
2019 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data showed a protective effect for CC genotype of rs1045485 variant and C-C haplotype of rs10931936-rs104548 in CASP8 in association with the decrease risk of breast cancer whereas rs10931936 showed no significant association.
|
31362911 |
2019 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.
|
27507139 |
2016 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CASP8 D302H was found to be only associated with breast cancer risk.
|
25553350 |
2014 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CASP8 D302H was associated with reduced breast cancer risk (for H carriers: pooled OR = 0.874, 95% CI: 0.834-0.917).
|
19629679 |
2010 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the CASP8 D302H positive females showed a 50% probability of being free of BC by the age of 78 versus the 2% of the CASP8 negative ones.
|
19214744 |
2010 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The minor allele of CASP8 D302H was significantly associated with a reduced risk of breast cancer (per-allele HR, 0.85; 95% CI, 0.76-0.97; P(trend) = 0.011) and ovarian cancer (per-allele HR, 0.69; 95% CI, 0.53-0.89; P(trend) = 0.004) for BRCA1 but not for BRCA2 mutation carriers.
|
20978178 |
2010 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent work in breast carcinoma has implicated the histidine variant of CASP8 D302H (rs1045485) as a protective risk allele.
|
20033885 |
2010 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer.
|
18823701 |
2009 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both approaches showed statistically significant decreased breast cancer risks for CASP8 D302H.
|
19367188 |
2009 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One such variant in the caspase-8 (CASP8) gene, D302H (rs1045485), has been confirmed to be associated with breast cancer risk, although the functional effect of this polymorphism (if any) is not yet clear.
|
19318553 |
2009 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in CASP8 at 2q33.1 have been associated with the risk of developing cancer, specifically, the D302H variant (rs1045485) with breast cancer in the European population and the -652 6N ins/del promoter variant (rs3834129) with multiple tumours including colorectal cancer (CRC) in the Chinese population.
|
18362937 |
2008 |