|
rs796065354
|
|
|
0.080 |
GeneticVariation |
BEFREE |
No hypersensitive estrogen receptor-alpha mutation (K303R) in Japanese breast carcinomas.
|
15026626 |
2004 |
|
rs796065354
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The A908G (Lys303-->Arg) change in the gene encoding oestrogen receptor-alpha (ER-alpha) creates a hypersensitivity to oestradiol and would have significant consequences if present in breast carcinoma, especially those treated with endocrine therapy.
|
15642159 |
2005 |
|
rs796065354
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This population-based study, the largest so far to screen for the ER-alpha A908G mutation in breast cancer, confirms the presence of the mutant in invasive breast tumors.
|
16280033 |
2005 |
|
rs1462893414
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The A908G (Lys303-->Arg) change in the gene encoding oestrogen receptor-alpha (ER-alpha) creates a hypersensitivity to oestradiol and would have significant consequences if present in breast carcinoma, especially those treated with endocrine therapy.
|
15642159 |
2005 |
|
rs1462893414
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This population-based study, the largest so far to screen for the ER-alpha A908G mutation in breast cancer, confirms the presence of the mutant in invasive breast tumors.
|
16280033 |
2005 |
|
rs188957694
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The majority of spontaneous and DMBA-induced carcinomas and sarcomas from p53(R270H/+)WAPCre mice is estrogen receptor alpha positive, and expression profiles of genes also implicated in human breast cancer appear similarly altered.
|
16166291 |
2005 |
|
rs200960801
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated three common ESR2 polymorphisms, rs1256049 (G1082A), rs4986938 (G1730A) and rs928554 (Cx+56 A-->G) for association to breast cancer risk.
|
16261413 |
2005 |
|
rs1364963022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no statistical difference in the C1qA[276A/G] allelic distribution between all subjects with breast cancer and controls.
|
16465510 |
2006 |
|
rs200282497
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no statistical difference in the C1qA[276A/G] allelic distribution between all subjects with breast cancer and controls.
|
16465510 |
2006 |
|
rs2234693
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we investigated breast cancer risk associated with genotypes and haplotypes resulting from four ESR1 single nucleotide polymorphisms (SNPs), rs746432, rs2234693, rs9340799, and rs1801132.
|
17268813 |
2007 |
|
rs796065354
|
|
|
0.080 |
GeneticVariation |
BEFREE |
ESR1 A908G mutation-positive breast cancer was significantly associated with a first-degree family history of breast cancer (odds ratio [OR] = 2.69, 95% confidence interval [CI] = 1.15 to 6.28), whereas mutation-negative breast cancer was not.
|
17553133 |
2007 |
|
rs9340799
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In this study, we investigated breast cancer risk associated with genotypes and haplotypes resulting from four ESR1 single nucleotide polymorphisms (SNPs), rs746432, rs2234693, rs9340799, and rs1801132.
|
17268813 |
2007 |
|
rs1801132
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In this study, we investigated breast cancer risk associated with genotypes and haplotypes resulting from four ESR1 single nucleotide polymorphisms (SNPs), rs746432, rs2234693, rs9340799, and rs1801132.
|
17268813 |
2007 |
|
rs1462893414
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ESR1 A908G mutation-positive breast cancer was significantly associated with a first-degree family history of breast cancer (odds ratio [OR] = 2.69, 95% confidence interval [CI] = 1.15 to 6.28), whereas mutation-negative breast cancer was not.
|
17553133 |
2007 |
|
rs201145204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR=1.81, 95% CI=1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk (adjusted OR=0.74, 95% CI=0.56-0.99).
|
17028982 |
2007 |
|
rs746432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated breast cancer risk associated with genotypes and haplotypes resulting from four ESR1 single nucleotide polymorphisms (SNPs), rs746432, rs2234693, rs9340799, and rs1801132.
|
17268813 |
2007 |
|
rs796065354
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Indeed, a breast cancer-associated mutation at K303 (K303R) alters methylation at K302 in vitro and in vivo.
|
18471979 |
2008 |
|
rs2144025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A multi-locus analysis of five adjacent tagSNPs suggested a region in ESR1 (between rs3003925 and rs2144025) for association with breast cancer risk (p = 0.001), but the result did not withstand adjustment for multiple comparisons (p = 0.086).
|
18271972 |
2008 |
|
rs3003925
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A multi-locus analysis of five adjacent tagSNPs suggested a region in ESR1 (between rs3003925 and rs2144025) for association with breast cancer risk (p = 0.001), but the result did not withstand adjustment for multiple comparisons (p = 0.086).
|
18271972 |
2008 |
|
rs796065354
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Expression of the K303R estrogen receptor-alpha breast cancer mutation induces resistance to an aromatase inhibitor via addiction to the PI3K/Akt kinase pathway.
|
19487288 |
2009 |
|
rs3798577
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This study provides evidence that polymorphisms CYP17 rs743572, CYP19 rs10046 and ER-alpha rs3798577 are associated with breast cancer risk among Chinese women.
|
18629629 |
2009 |
|
rs3020314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs3020314, tagging a region of ESR1 intron 4, is associated with an increase in breast cancer susceptibility with a dominant mode of action in European populations.
|
19126777 |
2009 |
|
rs761843408
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a large multiethnic case-control study, the G/A870 polymorphism conferred no significant risk for breast cancer overall or by stage or estrogen receptor (ER) status.
|
19287456 |
2009 |
|
rs767863538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A three-member fingerprint of S100P-correlated genes, consisting of GPRC5A, FXYD3, and PYCARD, conferred poor outcome in multiple breast cancer data sets, irrespective of estrogen receptor status but dependent on tumor size (P < 0.01).
|
19789341 |
2009 |
|
rs2234693
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This current analysis on 10,300 breast cancer cases and 16,620 controls on rs2234693 showed a borderline significant decreased breast cancer risk for CC and CC/CT carriers (CC vs. TT: OR, 0.92, 95% CI, 0.86-0.99; CC/CT vs. TT: OR, 0.95, 95% CI, 0.89-1.00).
|
19760036 |
2010 |