|
rs1219648
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
|
21263130 |
2011 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This meta-analysis of case-control studies provides strong evidence that fibroblast growth factor 2 (FGFR2; rs11200014, rs2981579, and rs1219648) polymorphisms are significantly associated with the BC risk.
|
29390357 |
2017 |
|
rs1219648
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
|
27354352 |
2016 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Genetic variation in FGFR2, identified by rs1219648, may account for a substantial fraction of breast cancer in Arab (12%), Ashkenazi (15%), and Sephardi Jewish (22%) populations.
|
18483326 |
2008 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To examine whether these variants contribute to risk of radiation-associated breast cancer in HL, we analyzed 2 independent case-control series, from the United Kingdom and The Netherlands, totaling 693 HL patients, 232 with breast cancer and 461 without. rs1219648, which annotates the FGFR2 gene, was associated with risk in both series (combined per-allele odds ratio = 1.59, 95% confidence interval: 1.26-2.02; P = .000111).
|
22144180 |
2012 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Two single-nucleotide polymorphisms, rs13387042 (2q35) and rs1219648 (FGFR2 gene), were found to be associated with breast cancer risk.
|
19789366 |
2009 |
|
rs1296941849
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we evaluated the association of the SNP rs1982073 (Leu10Pro) in transforming growth factor-beta 1 (TGFB1) gene and the SNP rs1219648 in fibroblast growth factor receptor 2 (FGFR2) gene with the risk and aggressiveness of breast cancer among women of Han nationality in North China.
|
20640597 |
2011 |
|
rs2420946
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We observed a statistically significant association between 4 SNPs and breast cancer risk and these 4 SNPs were in strong linkage disequilibrium in the Japanese population. rs2420946 was associated with a population-attributable risk of 17.7%.
|
19582883 |
2009 |
|
rs2420946
|
|
A |
0.770 |
GeneticVariation |
GWASCAT |
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk.
|
23544012 |
2013 |
|
rs2420946
|
|
|
0.770 |
GeneticVariation |
BEFREE |
This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk.
|
27966449 |
2017 |
|
rs2420946
|
|
|
0.770 |
GeneticVariation |
BEFREE |
To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC.
|
23184080 |
2013 |
|
rs2420946
|
|
|
0.770 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that rs2981582, rs1219648, and rs2420946 polymorphisms in FGFR2 are associated with elevated BC risk.
|
20364400 |
2010 |
|
rs2420946
|
|
|
0.770 |
GeneticVariation |
BEFREE |
In the haplotype analysis, the FGFR2 rs2981582 T / rs2420946 T / rs1219648 G haplotype (ht2) was associated with a significantly increased BC risk compared with the rs2981582 C / rs2420946 C / rs1219648 A haplotype in familial BC and in non-familial early-onset BC (OR = 1.32, 95 % CI 1.06-1.65, P = 0.012; OR = 1.46, 95 % CI 1.11-1.91, P = 0.004, respectively).
|
23225170 |
2013 |
|
rs2420946
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03-1.39), 1.24 (1.07-1.43), and 1.17 (1.01-1.36), respectively.
|
26421298 |
2015 |
|
rs2420946
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case-control studies.
|
20300826 |
2010 |
|
rs2912774
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
|
24493630 |
2014 |
|
rs2981575
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
FGFR2 rs2981575 had the strongest association with breast cancer risk (per allele HR = 1.28, 95% CI 1.18-1.39, ).
|
21060860 |
2010 |
|
rs2981575
|
|
|
0.710 |
GeneticVariation |
BEFREE |
FGFR2 rs2981575 had the strongest association with breast cancer risk (per allele HR = 1.28, 95% CI 1.18-1.39, ).
|
21060860 |
2010 |
|
rs2981578
|
|
C |
0.790 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs2981578
|
|
C |
0.790 |
GeneticVariation |
GWASCAT |
Genome-wide association study of breast cancer in the Japanese population.
|
24143190 |
2013 |
|
rs2981578
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The results suggest these polymorphisms, especially rs1966265 and rs2981578, might be candidate pharmacogenomics factors to the response and prognosis prediction for individualized CET-based chemotherapy in breast cancer patients.
|
30359238 |
2018 |
|
rs2981578
|
|
|
0.790 |
GeneticVariation |
BEFREE |
A significant association with BC risk was found with SNP rs2981578 (unadjusted per-allele odds ratio = 1.20, 95% confidence interval 1.03-1.41, P(trend) = 0.02), with the odds ratio estimate similar to that reported in European and Asian subjects.
|
19223389 |
2009 |
|
rs2981578
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Thus, the apparent increased risk of developing ERα positive breast cancer seems not to be caused by rs2981578 alone.
|
24265722 |
2013 |
|
rs2981578
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Our results suggest that the A allele and AA genotype of SNP rs2981578 appear to be protective factors associated with breast cancer, while the CT genotype of SNP rs3750817 is a putative risk factor.
|
21822685 |
2012 |
|
rs2981578
|
|
|
0.790 |
GeneticVariation |
BEFREE |
This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk.
|
27966449 |
2017 |