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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, more high-quality studies and that the covariates responsible for heterogeneity should be controlled to obtain a more conclusive response about the function of MTHFR C677T in cancer.
|
24744129 |
2014 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Two common polymorphisms are reported, C677T and A1298C, that are implicated in a number of human diseases, including cancer.
|
25921104 |
2015 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Two common variants in the MTHFR gene (C677T and A1298C) have been associated with reduced enzyme activity, thereby making MTHFR polymorphisms a potential candidate as a cancer-predisposing factor.
|
17712558 |
2007 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Common methylenetetrahydrofolate reductase gene variants (MTHFR C677T and A1298C) have been described to have opposite effects on cancer patients.
|
17488658 |
2007 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The C677T polymorphism of the methylene-tetrahydrofolate reductase (MTHFR) gene is associated with a reduction of catalytic activity and is suggested to modify cancer risk differently depending on folate status.
|
16950805 |
2006 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
However, in meta-analyses odds ratio for MTHFR c.677C>T</span> homozygotes versus noncarriers were 1.07 (95% CI: 1.01-1.12) for any cancer, 1.77 (1.17-2.68) for esophagus cancer, 1.40 (1.19-1.66) for gastric cancer and 0.85 (0.77-0.94) for colorectal cancer.
|
20473868 |
2011 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Multiplex PCR for simultaneous detection of 677 C-->T and 1298 A-->C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk.
|
12175537 |
2002 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study.
|
17573062 |
2007 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Accumulating evidence has indicated that two common genetic variants, C677T and A1298C, are associated with cancer risk.
|
20002681 |
2010 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
However, we did not find association between polymorphism in MTHFR C677T and risk of hypermethylation in P16, MGMT, hMLH1 and hMLH2 genes either in cancer or remote normal-appearing tissues.
|
23803092 |
2013 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer.
|
22194208 |
2011 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
To evaluate MTHFR C677T polymorphism in patients with head and neck squamous cell carcinoma and in individuals with no history of cancer, and to assess the association of this disease with clinical histopathological parameters.
|
21180947 |
2011 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Two common MTHFR polymorphisms, C677T and A1298C, which lead to an altered amino acid sequence, have been associated with a decreased enzyme activity and susceptibility to cancer suggesting that these genetic variants may modulate the risk of several malignancies.
|
18781847 |
2008 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk.
|
18322814 |
2008 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Some examples include the alanine-to-valine substitution at codon 222 (Ala222-->Val) [DNA: C-to-T substitution at nucleo-tide 677 (677C-->T)] in methylenetetrahydrofolate reductase (NADPH) and the cofactor FAD (in relation to cardiovascular disease, migraines, and rages), the Pro187-->Ser (DNA: 609C-->T) mutation in NAD(P):quinone oxidoreductase 1 [NAD(P)H dehy-drogenase (quinone)] and FAD (in relation to cancer), the Ala44-->Gly (DNA: 131C-->G) mutation in glucose-6-phosphate 1-dehydrogenase and NADP (in relation to favism and hemolytic anemia), and the Glu487-->Lys mutation (present in one-half of Asians) in aldehyde dehydrogenase (NAD + ) and NAD (in relation to alcohol intolerance, Alzheimer disease, and cancer).
|
11916749 |
2002 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR variants may cause genomic hypomethylation, which may lead to the development of cancer, and MTHFR gene polymorphisms (especially C677T and A1298C) are known to influence predispositions for cancer development.
|
26745044 |
2015 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The T allele of MTHFR C677T was significantly more frequently found in controls than in patients with cancer.
|
25075036 |
2014 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
We performed a prospective study to evaluate the prevalence and clinical significance of four gene variations (factor V Leiden [FVL], factor II G20210A, factor XIII Val34Leu and MTHFR C677T) in cancer patients, with and without VTE.
|
12757770 |
2003 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Our objective was to evaluate the MTHFR C677T-A1298C polymorphisms in patients with breast cancer and in individuals with no history of cancer, to compare the levels of genetic damage and apoptosis under folic acid (FA) deficiency between patients and controls, and to assess associations with breast cancer.
|
22901194 |
2012 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk.
|
23076526 |
2013 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.
|
16777985 |
2006 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
When MTHFR C677T genotype frequencies in MSS CRC cases were compared to controls, individuals with homozygous variant genotype were at 19% reduced risk of cancer compared to wild type (OR = 0.81; 95% CI: 0.65-1.02).
|
17350979 |
2007 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Compared with the CC genotype of MTHFR C677T, the TT/TC of the genotype significantly increased the risk of the esophageal squamous cells dysplasia [OR, 2.25; 95% confidence interval (CI), 1.18-4.31]; the OR of esophageal squamous cancer was 1.58 (95% CI, 0.85-2.97) after adjustments for age, sex, and years of education.
|
18662591 |
2008 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Cancer risk may be increased in individuals with the homozygous genotype for the MTHFR 677C-->T polymorphism who have low status of methyl-related nutrients including folate.
|
14608109 |
2003 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is a genetic factor that has been associated with many pathologies, including cancer.
|
31170928 |
2019 |