|
rs3743078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study of 529 cases and 567 controls was performed to study the association of three SNPs (rs3743076, rs3743078, and rs3743073) in CHRNA3 with lung cancer risk in Chinese Han population using logistic regression models.
|
20234319 |
2010 |
|
rs578776
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations of SNPs in LOC123688 (rs10519203; odds ratio [OR] = 1.60, 95% confidence interval [CI] = 1.25 to 2.05, P = .00016), CHRNA5 (rs2036527; OR = 1.67, 95% CI = 1.26 to 2.21, P = .00031), and CHRNA3 (rs1051730; OR = 1.81, 95% CI = 1.26 to 2.59, P = .00137) genes with lung cancer risk reached Bonferroni-corrected levels of statistical significance (all statistical tests were two-sided).
|
20554942 |
2010 |
|
rs578776
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Gene polymorphisms of CHRNA3 (rs578776) and CHRNA4 (rs1044396 and rs2229959) were associated with the success of smoking cessation after the diagnosis of lung cancer, which should be considered in the management of smoking cessation after patients are diagnosed with lung cancer.
|
31402126 |
2020 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, the authors apply a novel method for mediation analysis, allowing for gene-environment interaction, to a lung cancer case-control study (1992-2004) conducted at Massachusetts General Hospital using 2 single nucleotide polymorphisms, rs8034191 and rs1051730, on 15q25.1.
|
22306564 |
2012 |
|
rs12910984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, we identified four novel SNPs (rs2036534C>T, rs667282C>T, rs12910984G>A, and rs6495309T>C) that were associated with significantly increased lung cancer risk and smoking behavior, which were all confirmed in the replication analyses [odds ratios (95% confidence intervals) in the dominant model: 1.39 (1.23-1.57; P = 2.3 x 10(-7)), 1.52 (1.35-1.71; P = 2.0 x 10(-12)), 1.44 (1.28-1.63; P = 2.7 x 10(-9)), and 1.43 (1.27-1.61; P = 2.6 x 10(-9)), respectively].
|
19491260 |
2009 |
|
rs6495309
|
|
|
0.040 |
GeneticVariation |
BEFREE |
However, we identified four novel SNPs (rs2036534C>T, rs667282C>T, rs12910984G>A, and rs6495309T>C) that were associated with significantly increased lung cancer risk and smoking behavior, which were all confirmed in the replication analyses [odds ratios (95% confidence intervals) in the dominant model: 1.39 (1.23-1.57; P = 2.3 x 10(-7)), 1.52 (1.35-1.71; P = 2.0 x 10(-12)), 1.44 (1.28-1.63; P = 2.7 x 10(-9)), and 1.43 (1.27-1.61; P = 2.6 x 10(-9)), respectively].
|
19491260 |
2009 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
|
29993116 |
2018 |
|
rs11637630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the haplotype analysis found that the haplotypes "TCAC" and "CTGT," composed of rs938682, rs12914385, rs11637630, and rs2869546, were associated with a 1.79-fold and 501-fold increased lung cancer risk, respectively.
|
25656608 |
2015 |
|
rs2869546
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the haplotype analysis found that the haplotypes "TCAC" and "CTGT," composed of rs938682, rs12914385, rs11637630, and rs2869546, were associated with a 1.79-fold and 501-fold increased lung cancer risk, respectively.
|
25656608 |
2015 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis demonstrated that the two common variations (rs8034191 and rs1051730) at 15q25 are a risk factor associated with increased LC susceptibility, but these associations vary in different ethnic populations.
|
24254305 |
2014 |
|
rs578776
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggested both rs578776 and rs938682 were significantly associated with the susceptibility of lung cancer.
|
26831765 |
2016 |
|
rs938682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggested both rs578776 and rs938682 were significantly associated with the susceptibility of lung cancer.
|
26831765 |
2016 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the chr15q25.1 region spanning the nicotinic receptors CHRNA3 and CHRNA5, we identified multiple SNPs associated with CPD (p<10(-3)), including rs1051730, which has been associated with nicotine dependence, smoking intensity and lung cancer risk.
|
19247474 |
2009 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that CHRNA3 gene rs1051730-A allele and AGPHD1 gene rs8034191-T allele might be risk-conferring factors for the development of lung cancer in Caucasians, but not in East-Asians.
|
22701590 |
2012 |
|
rs6495309
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our findings demonstrated that CHRNA3 gene rs6495309 polymorphism might be a risk factor for the development of lung cancer in Chinese.
|
25288178 |
2014 |
|
rs8040868
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, these finding suggested that rs1948(C > T) and rs8040868(T > C) could be meaningful as genetic markers for lung cancer risk in Chinese Han population.
|
29416783 |
2018 |
|
rs3743073
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Overall, we did not observe a significant association of each genotype of the two SNPs with risk of gastric cancer (TT/CT vs. CC: adjusted OR = 1.12,95 % CI = 0.86-1.45; p = 0.401 for rs667282 and GG/TG vs. TT: adjusted OR = 1.13,95 % CI = 0.90-1.43; p = 0.300 for rs3743073).The results of our study indicated that these two SNPs at the 15q25 locus did not modify gastric cancer risk and the reported risk SNP at 15q25 may be specific to lung cancer.
|
23576140 |
2013 |
|
rs7177514
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs8042059 and rs7177514 may increase lung cancer risk indirectly through smoking behavior in the Chinese Han population.
|
25656608 |
2015 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Similarly, neither CHRNA3 rs8034191 nor rs1051730 were associated with lung cancer risk.
|
20068085 |
2010 |
|
rs3743073
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in CHRNA3 rs3743073 (A>G) were determined using the TaqMan-MGB probe technique in 600 lung cancer cases and 600 normal controls.
|
23023782 |
2012 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Smoking behavior and COPD are mediators of the association between the single nucleotide polymorphism (SNP) rs1051730 and the risk of lung cancer.
|
20564069 |
2010 |
|
rs1051730
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and COPD severity in the general population is largely unknown.
|
22441734 |
2012 |
|
rs6495309
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The data show a statistical association and suggest biological plausibility that the rs6495309T>C polymorphism contributed to increased risks and poor prognosis of both COPD and lung cancer.
|
23056235 |
2012 |