|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A subset of melanomas carrying a B-Raf proto-oncogene, serine/threonine kinase gene (BRAF) V600E mutation, which is the most common targetable mutation in melanoma, arise in association with a melanocytic nevus that is also harboring a BRAF V600E mutation.
|
29653212 |
2018 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We provided genetic evidence that Mitf E318K enhances BRaf V600E -induced nevus formation in vivo (mean nevus number for Mitf E318K , BRaf V600E vs Mitf WT , BRaf V600E , 68 vs 44, difference = 24, 95% CI = 9.1 to 38.9, P = .006).
|
28376192 |
2017 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The absence of the BRAF V600E mutation within a changing naevus supports the theory that BRAFi stimulates the proliferation of wild-type BRAF cells.
|
25380183 |
2015 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Nine cases presented concomitant BRAF and NRAS mutations, including one case in which both the melanoma and the adjacent naevus harboured V600E and Q61K double mutations.
|
25857817 |
2015 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Of the primary melanomas with an associated naevus (n = 29), 55% were BRAF(V600</span>E) mutant with 100% concordance between the melanoma and associated naevus.
|
24614711 |
2014 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
There was no significant association between BRAF(V600E) mutation and sex, histologic type, the Clark level, the Breslow index, solar elastosis, angiolymphatic and perineural invasion, satellitosis, and coexisting nevus.
|
24471189 |
2014 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
All neoplastic melanocytes within such a nevus would be expected to carry the BRAF mutation, and thus we evaluated the frequency of cells with BRAF(V600E) mutations within acquired nevi by droplet digital polymerase chain reaction.
|
23690527 |
2013 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The predominant BRAF mutation T1799A (V600E) was detected in 18 nevi; 1 nevus had a novel A1781G (D594V) mutation in the same gene and 3 nevi had mutations in codon 61 of the N-ras gene.
|
15009715 |
2004 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Among 13 lesions with structural changes, BRAF(V599E) mutations were found in 4 (3 melanomas and 1 nevus).
|
15373778 |
2004 |