Gene: ERBB2 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs758222990
rs758222990
ERBB2 ; MIR4728
T 0.700 CausalMutation CLINVAR Activating HER2 mutations in HER2 gene amplification negative breast cancer. 23220880

2013
dbSNP: rs121913470
rs121913470
ERBB2
C 0.700 GeneticVariation CLINVAR Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. 22046346

2011
dbSNP: rs121913471
rs121913471
ERBB2 ; MIR4728
C 0.700 GeneticVariation CLINVAR Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. 22046346

2011
dbSNP: rs121913470
rs121913470
ERBB2
C 0.700 GeneticVariation CLINVAR EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation. 18413839

2008
dbSNP: rs1057519738
rs1057519738
ERBB2 ; MIR4728
A 0.700 CausalMutation CLINVAR Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. 16397024

2006
dbSNP: rs121913468
rs121913468
ERBB2
T 0.700 CausalMutation CLINVAR Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. 16397024

2006
dbSNP: rs121913468
rs121913468
ERBB2
C 0.700 CausalMutation CLINVAR Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. 16397024

2006
dbSNP: rs758222990
rs758222990
ERBB2 ; MIR4728
T 0.700 CausalMutation CLINVAR Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. 16397024

2006
dbSNP: rs777081311
rs777081311
ERBB2
0.010 GeneticVariation BEFREE Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. 27905104

2017
dbSNP: rs1058808
rs1058808
ERBB2
0.010 GeneticVariation BEFREE However, we found significant differences in the distribution of Ile655Val (p = 0.03) and Ala1170Pro (p = 0.01) genotypes between normal breast and breast tumor tissues. 27788409

2016
dbSNP: rs1136201
rs1136201
ERBB2
0.010 GeneticVariation BEFREE However, we found significant differences in the distribution of Ile655Val (p = 0.03) and Ala1170Pro (p = 0.01) genotypes between normal breast and breast tumor tissues. 27788409

2016