Carcinoma
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
In addition, aberrant methylation of the B4GALNT2 gene was strongly correlated with Epstein-Barr virus-associated gastric carcinomas and occurred coincidentally with hypermethylation of the ST3GAL6 gene.
|
18485915 |
2008 |
Stomach Neoplasms
|
0.010 |
PosttranslationalModification
|
group |
LHGDN |
DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
|
18485915 |
2008 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The results indicate that the occurrence of CD75s- and iso-CD75s-gangliosides in tumor tissues is largely independent of the transcriptional expression of ST6GAL1 and ST3GAL6, respectively.
|
21147760 |
2011 |
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the ST3GAL6 expression was significantly diminished in HCCs (P = 0.003).
|
21147760 |
2011 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
We found that genes involved in the synthesis of sialyl-Lewis x (sLe(x); FUT3, FUT4, and ST3GAL6) are significantly increased in estrogen receptor alpha-negative (ER-negative) tumors compared with ER-positive ones.
|
22025563 |
2011 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Through Preliminary validation, there were two genes (St3gal6, Opcml) in thirty top-ranking genes shown hypermethylated in six pairs of CRC and adjacent normal mucosa.
|
23471507 |
2013 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In support of our in vitro findings, we demonstrate significantly reduced homing and engraftment of ST3GAL6 knockdown MM cells to the bone marrow niche in vivo, along with decreased tumor burden and prolonged survival.
|
25061176 |
2014 |
Multiple Myeloma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study we demonstrate that knockdown of ST3GAL6 results in a significant reduction in levels of α-2,3-linked sialic acid on the surface of MM cells with an associated significant reduction in adhesion to MM bone marrow stromal cells and fibronectin along with reduced transendothelial migration in vitro.
|
25061176 |
2014 |
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these data indicate that ST3GAL6 promotes cell growth, migration, and invasion and mediates the effect of miR-26a through the Akt/mTOR signaling pathway in HCC.
|
27906498 |
2017 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, these data indicate that ST3GAL6 promotes cell growth, migration, and invasion and mediates the effect of miR-26a through the Akt/mTOR signaling pathway in HCC.
|
27906498 |
2017 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Bioinformatic analysis further indicated a mechanism by which HIF-1α can regulate ST3GAL6 expression and the relationship within the intrinsic characteristics of TNBC tumors.
|
29894296 |
2018 |
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Bioinformatic analysis further indicated a mechanism by which HIF-1α can regulate ST3GAL6 expression and the relationship within the intrinsic characteristics of TNBC tumors.
|
29894296 |
2018 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The correlation between ST3Gal6-AS1 and ST3Gal6 was further validated in several types of CRC cell lines.
|
30613961 |
2019 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA ST3Gal6-AS1/ST3Gal6 axis mediates colorectal cancer progression by regulating α-2,3 sialylation via PI3K/Akt signaling.
|
30613961 |
2019 |