Fuchs Endothelial Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Three genes (MBNL1, KIF13A, AKAP13) that were previously identified as misspliced in patients with a CTG TNR expansion and FECD disease (RE+/FECD+) were found normally spliced in RE+/FECD- samples.
|
31469403 |
2019 |
HTLV-I Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The mechanism of p47 degradation is primarily dependent on activation of lysosomal-autophagy and the autophagy is activated in most of the HTLV-infected and ATLL cells, suggesting that the p47 degradation may be a first key molecular event during HTLV-1 infection to T-cells as a connector of two important signaling pathways, NF-κB and autophagy.
|
30837480 |
2019 |
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we identified the XIAP enzymatic substrate p47 as a positive regulator of the <i>I. scapularis</i> IMD network.
|
30559180 |
2019 |
Fibroid Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because AKAP13 augmented nuclear receptor signaling in other tissues, we sought to determine whether AKAP13 might influence PR signaling in fibroids.
|
30239831 |
2019 |
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mechanism of p47 degradation is primarily dependent on activation of lysosomal-autophagy and the autophagy is activated in most of the HTLV-infected and ATLL cells, suggesting that the p47 degradation may be a first key molecular event during HTLV-1 infection to T-cells as a connector of two important signaling pathways, NF-κB and autophagy.
|
30837480 |
2019 |
Uterine Fibroids
|
0.010 |
Biomarker
|
group |
BEFREE |
Because AKAP13 augmented nuclear receptor signaling in other tissues, we sought to determine whether AKAP13 might influence PR signaling in fibroids.
|
30239831 |
2019 |
T-Cell Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, using the murine LBC T-cell lymphoma, we found that cyclophosphamide significantly increased EVs yield.
|
30777349 |
2019 |
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ASE reduced oxidative damage markers (TBARS, carbonyl levels and 8-isoprostane) in D and DH associated with a decrease in Nox 4 and p47 subunit expression and increase in antioxidant enzyme activity in both groups (SOD, catalase and GPx).
|
28105508 |
2018 |
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
ASE reduced oxidative damage markers (TBARS, carbonyl levels and 8-isoprostane) in D and DH associated with a decrease in Nox 4 and p47 subunit expression and increase in antioxidant enzyme activity in both groups (SOD, catalase and GPx).
|
28105508 |
2018 |
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The general aim of the LBC ONC is to improve treatment of hematopoietic neoplasms by eradicating cancer-initiating and disease-propagating cells, also known as leukemic stem cells (LSC) in the context of leukemia.
|
30006759 |
2018 |
Liver Cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We used LBC, based on SurePathTM (BD Diagnostics) technology, to screen 96 peritoneal fluid samples from patients with known malignancies and from 10 control patients with cirrhosis.
|
30024911 |
2018 |
Myeloproliferative disease
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition, the concept of preleukemic (premalignant) neoplastic stem cells (pre-L-NSC) was coined by the LBC ONC and was tested in myelodysplastic syndromes and myeloproliferative neoplasms.
|
30006759 |
2018 |
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The hypothalamus and pituitary gland are implicated in the development and exacerbation of OCD and obesity and have strong AKAP13 expression.
|
29653158 |
2018 |
Obsessive-Compulsive Disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The hypothalamus and pituitary gland are implicated in the development and exacerbation of OCD and obesity and have strong AKAP13 expression.
|
29653158 |
2018 |
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tuberculosis in Pap samples with emphasis on LBC: Caught only when thought.
|
29193907 |
2018 |
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Akap13 haploinsufficiency led to sex-dependent, compulsive-like behavioral changes in a murine model.
|
29653158 |
2018 |
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Clozapine, LY294002, or p47 <sup>phox</sup> knockout significantly ameliorated social withdrawal and recognition memory deficits produced by phencyclidine.
|
30207504 |
2018 |
Hematopoietic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The general aim of the LBC ONC is to improve treatment of hematopoietic neoplasms by eradicating cancer-initiating and disease-propagating cells, also known as leukemic stem cells (LSC) in the context of leukemia.
|
30006759 |
2018 |
Childhood Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The general aim of the LBC ONC is to improve treatment of hematopoietic neoplasms by eradicating cancer-initiating and disease-propagating cells, also known as leukemic stem cells (LSC) in the context of leukemia.
|
30006759 |
2018 |
Cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We used LBC, based on SurePathTM (BD Diagnostics) technology, to screen 96 peritoneal fluid samples from patients with known malignancies and from 10 control patients with cirrhosis.
|
30024911 |
2018 |
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In the colorectal cancer, AKAP13 and ROCK1/2 were highly expressed in adenocarcinoma compared to the control tissue and low-grade dysplasia.
|
28434818 |
2017 |
Cholera
|
0.010 |
Biomarker
|
disease |
BEFREE |
In mouse immunization experiments, intranasal immunization with rec47 alone or with rec47 plus heat-labile enterotoxin B subunit from <i>Escherichia coli</i> or plus cholera toxin (CT) as adjuvants induced a higher amount of rec47-specific antibodies than intramuscular immunization with p47 alone or with p47 plus pBOOST2-samIRF7/3 (pB) as adjuvant.
|
28719308 |
2017 |
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that AKAP13 and ROCK are involved in mucosal response at early injury and restitution during healing in DSS-induced colitis in mice.
|
28535907 |
2017 |
Idiopathic Pulmonary Fibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For rs62025270, the allele A associated with increased susceptibility to IPF was also associated with increased expression of AKAP13 mRNA in lung tissue from patients who had lung resection procedures (n=1111).
|
29066090 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, three hub genes including PLEKHG5 (T2D: OR=1, P=1; CAD: OR=1.12, P=0.006), TIAM1 (T2D: OR=1, P=1; CAD: OR=1.48, P=0.004) and AKAP13 (T2D: OR=1, P=1; CAD: OR=1.38, P=0.001) were hub genes unique to CAD.
|
24508273 |
2014 |