TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease CTD_human The results of the present study suggest that TPH2 gene expression in the midbrain part of the DRN is implicated in depression and stress response, as well as in the antidepressant fluoxetine action. 17950541 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE The haplotype block in the promoter region of TPH2 showed significant associations with depression values during pregnancy and 6-8 months afterwards. 22721547 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models. 23547810 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE The effect of TPH2 haplotypes on risk-taking was independent of current depression and anxiety symptoms, neuroticism and impulsiveness scores. 20043001 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE While genetic association and mRNA expression studies implicate the tryptophan hydroxylase isoform-1 gene (TPH1) in depression and suicidality, the TPH1 gene is 150-fold less expressed in mouse brain than TPH2. 15941494 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE We hypothesize that functional polymorphisms (TPH2: rs7305115, 5-HTTLPR and rs25531) within both genes contribute to the risk of depressive disorders after childhood abuse in adult life. 25214390 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Although the role of the TPH2 mutation in depression had drawn attention previously, this has not been replicated either. 17239033 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Previous studies found that mutations on the TPH2 locus in humans were associated with depression and studies of mice and studies of rhesus macaques have shown that the TPH2 locus was involved with aggressive behavior. 21765945 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE We studied mice with an analogous mutation (TPH2-R439H), which results in a 60%-80% decrease in levels of 5-HT in the central nervous system and behaviors associated with depression in humans. 31071306 2019