|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We determined the presence of the R219K variant in the ABCA1 gene by polymerase chain reaction (PCR) and restriction analysis in 301 patients with and without CAD.
|
20303467 |
2010 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We studied the association of four polymorphisms in the ABCA1 gene (G1051A, G2706A, G2868A and -565C/T) with lipid profile and coronary artery disease.
|
21130966 |
2010 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, common genetic variations of ABCA1 had a moderate influence on HDL-C levels and/or coronary heart disease in patients with T2D.These 2 effects were independent.
|
19059534 |
2009 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease.
|
19673941 |
2009 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several studies have investigated the influence of ABCA1 variation on lipid metabolism and coronary heart disease, but they have resulted in controversial and inconsistent results.
|
18706283 |
2008 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The role of ABCA1 C69T and G-191C gene polymorphisms on plasma lipid levels of patients with coronary artery disease was investigated.
|
18468402 |
2008 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the ATP-binding cassette transporter 1 gene with decreased HDL-cholesterol levels and coronary artery disease.
|
18996286 |
2008 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results suggest that defective ABCA1 function in cholesterol-loaded macrophages is one potential contributor to the impaired RCT process and the increased coronary heart disease risk in subjects with familial low HDL.
|
17372331 |
2007 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We examined common promoter and non-synonymous coding polymorphisms in relation to age of symptom onset in a group of CAD patients (n = 1164), and also carried out in vitro assays to test effects of the promoter variations on ABCA1 promoter transcriptional activity and effects of the coding variations on ABCA1 function in mediating cellular cholesterol efflux.
|
17412755 |
2007 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
We examined common promoter and non-synonymous coding polymorphisms in relation to age of symptom onset in a group of CAD patients (n = 1164), and also carried out in vitro assays to test effects of the promoter variations on ABCA1 promoter transcriptional activity and effects of the coding variations on ABCA1 function in mediating cellular cholesterol efflux.
|
17412755 |
2007 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations in ABCA1, as seen in Tangier disease, result in accumulation of cellular cholesterol, reduced plasma high-density lipoprotein cholesterol, and increased risk for coronary artery disease.
|
16704350 |
2006 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The ATP-binding cassette transporter A1 (ABCA1) mediates reverse cholesterol transport, polymorphisms have been shown to influence the levels of cholesterol and of HDL and the risk of coronary artery disease.
|
16596262 |
2006 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop).
|
15657615 |
2005 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
ABCA1 predicted HDL (mean, GG = 36.4 mg/dL, AA = 39.2 mg/dL; P = .02) but not CAD (GG 74%, AA 75%; adjusted P = .96, OR = 0.99).
|
16086925 |
2005 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis.
|
15528481 |
2005 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
ABCA1 gene was initially implicated in Tangier disease and familial hypoalphalipoproteinemia and has been shown to be associated with coronary artery disease and atherosclerosis as well.
|
16009332 |
2005 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 gene polymorphisms but not haplotypes are involved in the variability of plasma ApoA1 and the susceptibility to coronary artery disease.
|
14962947 |
2004 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In subjects with coronary artery disease (CAD+), the prevalence of FABP-2 54TT genotype was higher (16.5% versus 5.2%) and that of ABCA1 219RK and KK genotypes lower (33.0% versus 51.5%) than in subjects with no CAD.
|
15135251 |
2004 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia.
|
12700893 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We explored if polymorphisms in the ABCA1 gene are associated with CAD and variations in plasma lipid levels, especially HDL-C, and whether the associations may depend on ethnicity.
|
12709788 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Novel polypyrimidine variation (IVS46: del T -39...-46) in ABCA1 causes exon skipping and contributes to HDL cholesterol deficiency in a family with premature coronary disease.
|
14576201 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, variants in ATP-binding cassette transporter A1 (ABCA1) were demonstrated to be associated with increased level of high density lipoprotein cholesterol (HDL-C) and decreased risk of coronary artery disease (CAD) in Caucasians.
|
12860256 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ATP-binding cassette transporter A1 locus is not a major determinant of HDL-C levels in a population at high risk for coronary heart disease.
|
12535741 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A common variant in the ABCA1 gene is associated with a lower risk for premature coronary heart disease in familial hypercholesterolaemia.
|
12624133 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Patients with Tangier disease have mutations in the gene encoding ABCA1, which result in functionally impaired protein, a marked deficiency in HDL cholesterol, and a high risk of premature CAD.
|
12679198 |
2003 |