|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibition of the IGF-1R or the Src-ERK pathway should be considered, therefore, as an adjuvant therapy in PCa.
|
19250214 |
2009 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
We examined the impact of EGFR-ERK signaling on poly (ADP-ribose) polymerase (PARP) activation following ionizing irradiation of human prostate cancer (PCa) cell lines displaying marked differences in ERK dependence.
|
17295209 |
2007 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that aberrant loss of MAPK/ERK activity in prostate cancer may play a pivotal role in the malignant phenotype, and provide evidence that interventions aimed at bypassing the signaling block are able to effectively reverse neoplastic unchecked cell proliferation.
|
17143532 |
2007 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
We evaluated the contribution of EphB2 to inherited PC susceptibility in African Americans (AA) by screening the gene for germline polymorphisms.
|
16155194 |
2006 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies associated the CAPB locus with familial risk of brain and prostate cancers.
|
16507112 |
2006 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
UNIPROT |
We evaluated the contribution of EphB2 to inherited PC susceptibility in African Americans (AA) by screening the gene for germline polymorphisms.
|
16155194 |
2006 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here we have analyzed the EPHB2 gene for germline alterations in 101 individuals either with 1) CRC and a personal or family history of prostate cancer (PC), or 2) intestinal hyperplastic polyposis (HPP), a condition associated with malignant degeneration such as serrated adenoma and CRC.
|
16740153 |
2006 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Such a "mutatomics" screening of prostate cancer cell lines led to the identification of inactivating mutations in the EPHB2 gene.
|
16037637 |
2005 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Early linkage results have provided targeted candidate regions for prostate cancer susceptibility loci, including HPC1 on chromosome 1q23-25, PCAP on chromosome 1q42-43, CAPB on chromosome 1p36, linkage to chromosome 8p22-23, HPC2 on chromosome 17p, HPC20 on chromosome 20q13, and HPCX on chromosome Xq27-28.
|
14749351 |
2004 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In total, 126 individuals (including 89 men with prostate cancer) were genotyped using markers that map to five prostate cancer susceptibility loci, namely HPC1 at 1q24-25, PCAP at 1q42.2-43, CAPB at 1p36, HPC20 on chromosome 20, and HPCX at Xq27-28.
|
14735201 |
2004 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Taken together with studies indicating that EphB2 may have an essential role in cell migration and maintenance of normal tissue architecture, our findings suggest that mutational inactivation of EPHB2 may be important in the progression and metastasis of prostate cancer.
|
15300251 |
2004 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
The utility of the method is well-illustrated by a series of observations linking the ephrin receptor EPHB2 to prostate cancer.
|
15340430 |
2004 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
UNIPROT |
Taken together with studies indicating that EphB2 may have an essential role in cell migration and maintenance of normal tissue architecture, our findings suggest that mutational inactivation of EPHB2 may be important in the progression and metastasis of prostate cancer.
|
15300251 |
2004 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis of high-risk prostate cancer (PC) families with at least one confirmed case of primary brain cancer (BC) has identified a region of genetic linkage on chromosome 1p36 termed CAPB.
|
11536309 |
2001 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these results show that MAPK pathways ERK, JNK/SAPK, and P38-MAPK represent a significant component in the regulation of u-PA expression in human CaP.
|
11676474 |
2001 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Prostate cancer susceptibility loci that have been reported so far include HPC1 (1q24-q25), PCAP (1q42-q43), HPCX (Xq27-q28), CAPB (1p36), HPC20 (20q13), HPC2/ELAC2 (17p11) and 16q23.
|
11673416 |
2001 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY (finding)
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY (finding)
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY (finding)
|
0.400 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Ependymoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes.
|
26075792 |
2015 |
|
Ependymoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
We propose that EphB2 mediated ependymoma development is a multifactorial process requiring microenvironment directed receptor activation, resulting in changes in the phosphorylation status of key regulatory proteins, maintenance of a stem-like state and cellular proliferation.
|
25801123 |
2015 |
|
Ependymoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
The transcriptome of human supratentorial ependymomas with amplified EPHB2 and deleted INK4A/ARF matched only that of embryonic cerebral Ink4a/Arf(-/-) NSCs.
|
20639864 |
2010 |
|
Prostate cancer, familial
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
We have previously shown an association between an EphB2 germline nonsense variant and risk of familial prostate cancer among African American Men (AAM).
|
21603658 |
2011 |
|
Prostate cancer, familial
|
0.310 |
SusceptibilityMutation
|
disease |
ORPHANET |
A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.
|
16155194 |
2006 |