|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings suggest the functional importance of SIRT1 in regulating pathogenic tau acetylation and in suppressing the spread of tau pathology <i>in vivo</i><b>SIGNIFICANCE STATEMENT</b> In neurodegenerative disorders with inclusions of microtubule-associated protein tau, aberrant lysine acetylation of tau plays critical roles in promoting tau accumulation and toxicity.
|
29540553 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
During the past decade, sirtuin-1 (SIRT1) has been the focus of intense investigation and discussion because it regulates longevity in multiple organisms and has shown beneficial effects in a variety of models of neurodegenerative disorders.
|
23549885 |
2013 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
SIRT1 has been involved in many cellular processes and implicated in human diseases, such as obesity, type 2 diabetes, cancer and neurodegenerative diseases.
|
22885181 |
2012 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The human Sirtuin isoforms, SIRT1-7, are considered attractive therapeutic targets for aging-related diseases, such as type 2 diabetes, inflammatory diseases and neurodegenerative disorders.
|
29577959 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
SIRT1 and NRF2 stimulate anti-inflammatory mechanisms and have previously demonstrated therapeutic value in preclinical models of neurodegenerative disease.
|
29494741 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Sirtuins (SIRT1-7) are NAD(+)-dependent histone deacetylases (HDACs) that play an important role in the control of metabolism and proliferation and the development of age-associated diseases like oncologic, cardiovascular and neurodegenerative diseases.
|
23499872 |
2013 |
|
Neurodegenerative Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Perplexingly, manipulations that either increase or decrease Sirt1 activity have both been associated with a beneficial effect in animal models of ageing-associated disorders, such as neurodegenerative diseases.
|
19912989 |
2010 |
|
Neurodegenerative Disorders
|
0.400 |
Therapeutic
|
group |
CTD_human |
Thus, SIRT1 constitutes a unique molecular link between aging and human neurodegenerative disorders and provides a promising avenue for therapeutic intervention.
|
17581637 |
2007 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
SIRT1 gene has been connected to many cellular processes and implicated in human diseases, such as obesity, type 2 diabetes, cancer and neurodegenerative diseases.
|
22613205 |
2012 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
In this review, we focus on the role of SIRT1 in the neuroendocrine system and neurodegenerative diseases.
|
30416425 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Silent information regulator family protein 1 (SIRT1), a member of the NAD<sup>+</sup>-dependent protein deacetylases, has been shown to exhibit neuroprotective activities in animal models of various pathologies, including ischemic brain injury, subarachnoid hemorrhage and several neurodegenerative diseases.
|
28017962 |
2017 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Finally, SIRT1 plays protective roles in several neurodegenerative diseases including Alzheimer's, Parkinson's, and motor neuron diseases, which may relate to its functions in metabolism, stress resistance, and genomic stability.
|
24507186 |
2014 |
|
Neurodegenerative Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sirtuins (SIRT1-7; class III histone deactylases) modulate fundamental mechanisms in age-related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS).
|
22796962 |
2013 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Silent information regulator 1 (SIRT1) exerts neuroprotection in many neurodegenerative diseases.
|
29375306 |
2017 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
In this review, we will first summarize how SIRT1 in the brain relates to obesity, type 2 diabetes, and circadian synchronization, and then we discuss the neuroprotective roles of brain SIRT1 in the context of cerebral ischemia and neurodegenerative disorders.
|
30532738 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
This review examines experimental and clinical evidence relating to the potential role of SIRT1 and SIRT2, and their modulators in neurodegenerative diseases.
|
31812544 |
2020 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Since the first pan-HDAC inhibitor SAHA was approved by U.S. FDA 10 years ago, HDACs including SIRT1-7 have received significant attention due to the fact that aberrant histone deacetylase activtiy has been implicated in a variety of human diseases, such as cancers, virus infection, and neurodegenerative diseases.
|
28033734 |
2017 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
SIRT1 plays a key role in the pathophysiology of metabolic diseases and neurodegenerative disorders, and is considered to protect against age-related diseases including cancer.
|
26862948 |
2017 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Resveratrol, an activator of silent information regulator 2, homolog 1 (SIRT1), regulates cell destiny and is beneficial for neurodegenerative disorders.
|
29102593 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
In conclusion, we provide a novel perspective for the prediction of the therapeutic benefits of the modulation of SIRT1- and nucleolar-dependent pathways in metabolic and neurodegenerative diseases.
|
31110473 |
2019 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
LHGDN |
Thus, SIRT1 constitutes a unique molecular link between aging and human neurodegenerative disorders and provides a promising avenue for therapeutic intervention.
|
17581637 |
2007 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Presently, SIRT1 is gaining increasing importance in the development of innovative treatment strategies for cancer, neurodegenerative disorders and metabolic disease.
|
18774777 |
2008 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
It is important to recognize that oversight of programmed cell death by mTOR and SIRT1 requires a fine degree of precision to prevent the progression of neurodegenerative disorders.
|
29523769 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Therapeutic
|
group |
CTD_human |
SIRT1 activation confers neuroprotection in experimental optic neuritis.
|
17652729 |
2007 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
SIRT1 activation may be a viable target for treatment or prevention of neurodegenerative disorders.
|
28086917 |
2017 |