Leukemia, Myelocytic, Acute
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest the possibility that the H-ras-1 allelic pattern that is associated with acute myelogenous leukemia is distinct from that found in B-cell-derived malignancies.
|
1670614 |
1991 |
Leukemia, Myelocytic, Acute
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Oncogenic mutations in the KRAS2, NRAS, or FLT3 gene are detected in more than 50% of patients with de novo acute myeloid leukemia (AML).
|
14732923 |
2004 |
Leukemia, Myelocytic, Acute
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.
|
16923573 |
2006 |
Leukemia, Myelocytic, Acute
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We failed to find mutations in exons 1 and 2 of the K-RAS or Ha-RAS genes in any case except a single AML with a mutation in codon 61 of the K-RAS gene.
|
2183888 |
1990 |
Leukemia, Myelocytic, Acute
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis of proto-oncogenes in acute myeloid leukemia: loss of heterozygosity for the Ha-ras gene.
|
1967953 |
1990 |
Leukemia, Myelocytic, Acute
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Leukemia, Myelocytic, Acute
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Ha-ras polymorphism in myelodysplasia and acute myeloid leukaemia.
|
3288815 |
1988 |
Leukemia, Myelocytic, Acute
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HRAS1 and INS genes are relocated but not structurally altered as a result of the t(7;11)(p15;p15) in a clone from a patient with acute myeloid leukaemia (M4).
|
2713271 |
1989 |
Leukemia, Myelocytic, Acute
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Implications of NRAS mutations in AML: a study of 2502 patients.
|
16434492 |
2006 |
Leukemia, Myelocytic, Acute
|
0.500 |
CausalMutation
|
disease |
CGI |
|
|
|
Leukemia, Myelocytic, Acute
|
0.500 |
Biomarker
|
disease |
BEFREE |
In situ chromosome hybridization showed that the c-Ha-ras-1 oncogene localized to the breakpoint (p15) of chromosome #11 is translocated to the rearranged chromosome #7 in the AML case, whereas, it remained on the conserved region of the rearranged chromosome #11 in the CML case.
|
3315181 |
1987 |
Leukemia, Myelocytic, Acute
|
0.500 |
Biomarker
|
disease |
BEFREE |
Leukemic cells of another AML patient showed HRAS gene activation.
|
3122217 |
1987 |
Leukemia, Myelocytic, Acute
|
0.500 |
Biomarker
|
disease |
BEFREE |
To search for additional, novel RAS mutations, we sequenced all coding exons in NRAS, KRAS, and HRAS in 329 acute myeloid leukemia (AML) patients, 32 chronic myelomonocytic leukemia (CMML) patients, and 96 healthy individuals.
|
19075190 |
2009 |