|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Though the variants in the 3' untranslated region (UTR) of GRP78 gene were not associated with HCC risk, we wonder whether these polymorphisms affect survival of HCC patients.
|
21445355 |
2011 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, compared with allele A, rs391957 allele G was associated with higher levels of GRP78 mRNA and protein in HCC tissues.
|
23416888 |
2013 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis.
|
21779363 |
2011 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A case-control study was conducted on 576 HCC patients, and 539 age- and gender-matched healthy subjects to examine whether rs430397 polymorphism in the fifth intron of GRP78 gene is associated with the development and prognosis of HCC.
|
19533686 |
2009 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aims of this study were (i) to assess the association of two SNPs, rs430397 in GRP78 and rs738409 in PNPLA3 with the risk of developing HCC in a Sicilian association cohort and, (ii) to use a machine learning technique to establish a predictive combinatorial phenotypic model for HCC including rs430397 and rs738409 genotypes and clinical and laboratory attributes.
|
27888630 |
2016 |
|
Bipolar Disorder
|
0.320 |
GeneticVariation
|
disease |
LHGDN |
These findings suggested promotor polymorphisms of HSPA5 may affect the interindividual variability of ER stress response and may confer a genetic risk factor for bipolar disorder.
|
16168956 |
2005 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, transcriptional control through the use of the Grp78 promoter offers multiple novel approaches for human cancer gene therapy.
|
15212714 |
2004 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, we investigated the regulatory mechanisms of the grp78 gene in liver malignancy.
|
12713871 |
2003 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Glucose-regulated protein 78 kDa (GRP78/Bip), which has a role in cancer development, is one of the androgen response genes in prostate cell lines.
|
24583399 |
2014 |
|
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data provide the first evidence that the GRP78 rs391957 polymorphism can predict clinical outcome in localized GA and locally advanced CRC patients.
|
21382870 |
2011 |
|
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data provide the first evidence that GRP78 rs391957 and rs430397 polymorphisms could serve as markers to predict the risk of CRC.
|
23818965 |
2013 |
|
Tumor Cell Invasion
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A new polymorphism in the GRP78 is not associated with HBV invasion.
|
19842229 |
2009 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, transcriptional control through the use of the Grp78 promoter offers multiple novel approaches for human cancer gene therapy.
|
15212714 |
2004 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, we investigated the regulatory mechanisms of the grp78 gene in liver malignancy.
|
12713871 |
2003 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Glucose-regulated protein 78 kDa (GRP78/Bip), which has a role in cancer development, is one of the androgen response genes in prostate cell lines.
|
24583399 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Three years after baseline, 32.9% (97/295) of the T2DM patients had suffered the development of diabetic peripheral neuropathy and GRP78 rs391957 promoter polymorphism is a significant risk factor for the onset of type 2 diabetic peripheral neuropathy.
|
26005757 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The study does not support a role for promoter polymorphisms of GRP78 in T2D in a Chinese Han population, but it does provide a clue for association between low levels of fasting plasma glucose, HbA1c and fasting insulin, and the -415AA/-180GG model.
|
23402331 |
2013 |
|
Hepatitis B
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
These observations do not support a role for GRP78 polymorphisms in HBV infection in a predominantly Chinese Han population.
|
20525207 |
2010 |
|
Hepatitis B
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis.
|
21779363 |
2011 |
|
Adenocarcinoma
|
0.060 |
GeneticVariation
|
group |
BEFREE |
This study investigated the effectiveness of HSV-tk activation as gene therapy for gastroesophageal junction and gastric adenocarcinomas using either the stress-inducible Grp78 promoter or the murine leukemia virus long-terminal repeat (LTR) promoter.
|
19277794 |
2009 |
|
Diabetes Mellitus
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Common variants at PERK and BIP loci contributed to the risk of prediabetes, and the genetic variations in JNK and XBP1 genes are associated with diabetes-related clinical parameters in this Chinese population.
|
24985580 |
2014 |
|
Neuroblastoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Two GRP78 polymorphisms rs391957 (C>T) and rs430397 (G>A) were detected in 105 NB cases and 145 healthy controls using the polymerase chain reaction fragment length polymorphism technique.
|
28054532 |
2017 |
|
Central neuroblastoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Two GRP78 polymorphisms rs391957 (C>T) and rs430397 (G>A) were detected in 105 NB cases and 145 healthy controls using the polymerase chain reaction fragment length polymorphism technique.
|
28054532 |
2017 |
|
Childhood Neuroblastoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Two GRP78 polymorphisms rs391957 (C>T) and rs430397 (G>A) were detected in 105 NB cases and 145 healthy controls using the polymerase chain reaction fragment length polymorphism technique.
|
28054532 |
2017 |
|
Alzheimer's Disease
|
0.050 |
GeneticVariation
|
disease |
LHGDN |
Therefore, our preliminary results may suggest a protective role of the HSPA5 -415 A/-180 G allele in Taiwanese AD susceptibility.
|
18781276 |
2008 |