HTR1D, 5-hydroxytryptamine receptor 1D, 3352

N. diseases: 26; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE New polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) not linked to schizophrenia in five Canadian pedigrees. 8104876 1993
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		0.030 Biomarker group BEFREE This study points to the 5-HT1D beta receptor subtype as the putative cerebrovascular target for migraine therapeutic agents. 8394988 1993
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease BEFREE Further studies should be carried out on the 5-HT1D binding site as it might represent a new tool in the understanding of the depressive illness. 8018797 1994
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease PSYGENET Further studies should be carried out on the 5-HT1D binding site as it might represent a new tool in the understanding of the depressive illness. 8018797 1994
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		0.030 Biomarker group BEFREE Inasmuch as one recent report found that mRNA encoding only the 5-HT1D beta receptor subtype was expressed by vascular smooth muscle of the central nervous system, the present findings suggest the importance of developing selective 5-HT1D alpha receptor agonists as a strategy to reduce the risk of myocardial infarction and possibly stroke that complicates the acute treatment of migraine headache. 8170966 1994
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.010 Biomarker disease BEFREE Inasmuch as one recent report found that mRNA encoding only the 5-HT1D beta receptor subtype was expressed by vascular smooth muscle of the central nervous system, the present findings suggest the importance of developing selective 5-HT1D alpha receptor agonists as a strategy to reduce the risk of myocardial infarction and possibly stroke that complicates the acute treatment of migraine headache. 8170966 1994
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.010 Biomarker group BEFREE Inasmuch as one recent report found that mRNA encoding only the 5-HT1D beta receptor subtype was expressed by vascular smooth muscle of the central nervous system, the present findings suggest the importance of developing selective 5-HT1D alpha receptor agonists as a strategy to reduce the risk of myocardial infarction and possibly stroke that complicates the acute treatment of migraine headache. 8170966 1994
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.010 Biomarker phenotype BEFREE We report on 5-HT1A, 5-HT1D, and 5-HT2 binding sites in 23 control subjects and 18 suicide victims subdivided according to the method of death and the previous existence of depressive symptoms. 8018797 1994
CUI: C0020649
Disease: Hypotension
Hypotension 		0.300 Biomarker phenotype CTD_human Interactions of GR127935, a 5-HT(1B/D) receptor ligand, with functional 5-HT receptors. 9109356 1997
CUI: C0002963
Disease: Angina Pectoris, Variant
Angina Pectoris, Variant 		0.010 Biomarker disease BEFREE We demonstrated the supersensitivity of isolated coronary artery to ergonovine, 5-HT, and sumatriptan, a 5-HT1D receptor agonist, in a patient with variant angina. 9440599 1998
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.300 Biomarker disease CTD_human Single photon emission computed tomography of the brain with Tc-99m HMPAO during sumatriptan challenge in obsessive-compulsive disorder: investigating the functional role of the serotonin auto-receptor. 10621951 1999
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.040 Biomarker disease LHGDN Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. 12740597 2003
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.040 Biomarker disease BEFREE The combined statistical genetic evidence suggests that HTR1D and OPRD1 or linked genes may be involved in the etiology of AN. 12740597 2003
CUI: C0013473
Disease: Eating Disorders
Eating Disorders 		0.020 Biomarker group BEFREE Serotonergic and opioidergic neurotransmitter system alterations have been observed in people with eating disorders; the genes for the serotonin 1D receptor (HTR1D) and the opioid delta receptor (OPRD1) are found on chr1p36.3-34.3, a region identified by our group in a linkage analysis of anorexia nervosa (AN). 12740597 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE Thus, the results do not support an association of the G861C polymorphism in the 5-HT1D(beta) autoreceptor gene with schizophrenia in the studied sample. 16059583 2005
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.010 GeneticVariation disease BEFREE The current study genotyped two variants of HTR1D gene in 272 ADHD trios of Chinese ethnicity, that is 1350T > C in the coding region and 1236A > G in 3'-UTR by the use of transmission disequilibrium test (TDT). 17099886 2006
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.040 GeneticVariation disease BEFREE Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa. 16806108 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.300 Biomarker disease CTD_human HTR1B and HTR2C in autism spectrum disorders in Brazilian families. 19038234 2009
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.010 GeneticVariation disease BEFREE The 5-HT1A, 5-HT1B, 5-HT1D, 5-HT3A and TPH1 showed no significant association with BPD for genotype, allele and haplotype analyses. 19032968 2009
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.040 GeneticVariation disease BEFREE We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. 20946355 2011
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.040 GeneticVariation disease BEFREE We confirmed that common single-nucleotide polymorphisms (SNPs) within OPRD1 (rs533123, P=0.0015) confer risk for AN, and obtained suggestive evidence that common SNPs near HTR1D (rs7532266, P=0.04) confer risk for restricting-type AN specifically. 21079607 2011
CUI: C0013473
Disease: Eating Disorders
Eating Disorders 		0.020 GeneticVariation group BEFREE We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. 20946355 2011
CUI: C0232600
Disease: Self-induced vomiting
Self-induced vomiting 		0.010 GeneticVariation disease BEFREE We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. 20946355 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease PSYGENET Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response. 21937687 2012
CUI: C0028754
Disease: Obesity
Obesity 		0.010 GeneticVariation disease BEFREE The HTR1D rs6300 polymorphism was showing a slight significance conferring risk for obesity (heavy weight gain group) under additive model. 22840963 2013