Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These results identify a GM-CSF/IL-17/IFN-γ axis that regulates inflammation in the central nervous system and suggest that a combination of cytokine-neutralizing therapies may be needed to dampen central nervous system autoimmunity.
|
28405624 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Interferon-γ (IFN-γ) secreting T helper (Th1) and IL-17 secreting T helper (Th17) cells are critical for several autoimmune diseases.
|
28095433 |
2017 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The systemic autoimmunity type-SLE was observed seven months after the application of TMPD, in which the animals from the negative control group (animals with damage and without any other treatment) developed articular inflammation, proteinuria, an increment of the antinuclear antibody titters and tissue pro-inflammatory cytokines levels (IL-1β, IL-6, TNF-α e IFN-γ) as well as the anti-inflammatory cytokine IL-10.
|
28587079 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Secretion of the inflammatory cytokine IFNγ, together with the acquisition of a T helper 1 (Th1)-like effector phenotype as observed in cancer, infection, and autoimmune diseases, is associated with loss of Treg suppressor function through an unknown mechanism.
|
27312110 |
2016 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Our findings highlight a role for Mal outside the TLR system and imply that genetic variation in TIRAP may be linked to other IFN-γ-related diseases including autoimmunity and cancer.
|
26885859 |
2016 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This meta-analysis indicates that the IFN-γ +874 T/A polymorphism may play a significant role in modifying the risk of autoimmune diseases in Caucasian, Latin American, and Middle Eastern subjects, and in particular shows that the IFN-γ +874 T/A polymorphism is associated with increased genetic susceptibility to idiopathic thrombocytopenic purpura and SLE.
|
26703437 |
2016 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Pathogenic functions of B cells in autoimmune diseases: IFN-γ production joins the criminal gang.
|
25727209 |
2015 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The findings in our study suggest that STAT1 rs1467199 SNP plays a potential role in the IFN-γ dependent development of autoimmunity in children with ITP.
|
25707685 |
2015 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In this review we will discuss the role of the X chromosome encoded toll-like receptor 7 (TLR7) and interferon gamma (IFNγ) in the development of autoimmunity.
|
25541140 |
2015 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate the consequences of a chronic IFN-γ milieu on B220(+) cell types and in particular the impact of MZB cell loss on MZM function in autoimmunity.
|
24583068 |
2014 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
A marked reduction of IL-2 was also observed for all CT relatives with autoimmunity and a lack of IFN-γ production was observed for the younger brother of the index patient, heterozygous for the polymorphism.
|
22809281 |
2013 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Interferon-gamma (IFN-γ) is a paracrine inhibitor of melanocytes and genetic variability due to intron 1 polymorphisms in IFNG has been reported to be associated with increased risk for several autoimmune diseases.
|
23777204 |
2013 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Signal transducer and activator of transcription 4 (STAT4) transmits signals induced by interleukin-12, interleukin-23 and interferon-γ, which are key cytokines and play important roles in the development of autoimmune diseases.
|
23727609 |
2013 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition, the anti-apoptotic gene BCL3, interferon-γ (IFNG), and the vitamin D receptor (VDR) gene physically interact with significantly many genes that tend to be differentially expressed in PBMCs of patients with the analyzed autoimmune diseases.
|
23190644 |
2013 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
A considerable proportion of reported cases of anti-IFN-γ autoantibodies show either clinical or laboratory evidence of autoimmune disease.
|
23243276 |
2013 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Th cytokines IFN-γ and IL-17 are linked to the development of autoimmune disease.
|
23630349 |
2013 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These findings indicate that TGP inhibits autoimmunity in SLE patients possibly by inducing Treg cell differentiation, which may in turn be due to its ability to regulate the methylation status of the Foxp3 promoter and activate IFN-γ and IL-2 signaling.
|
22406048 |
2012 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We conclude that a shift in immunodominance of self-antigenic determinants of Col-V results in induction of IFN-γ and IL-17 with loss of tolerance leading to autoimmunity to Col-V, which leads to chronic lung allograft rejection.
|
22132895 |
2012 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
An epigenetic mechanism for high, synergistic expression of indoleamine 2,3-dioxygenase 1 (IDO1) by combined treatment with zebularine and IFN-γ: potential therapeutic use in autoimmune diseases.
|
22424783 |
2012 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In contrast, inhibition of DP IV and APN activities selectively suppresses lymphocyte functions including proliferation and production of the T helper type (Th)1 cytokine IFN-γ, the Th17 cytokine IL-17, as well as TNF-α, and ameliorates autoimmunity in vivo.
|
21802166 |
2011 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The T-box transcription factor T-bet is a key regulator for the lineage commitment in CD4 Th1 cells and CD8 T cells by activating the hallmark production of interferon-γ, and its expression level is linked to autoimmune diseases.
|
20977921 |
2011 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Interferon-gamma is a potent Th1-type cytokine and a key molecule in the pathogenesis of autoimmune diseases including lupus nephritis.
|
20167631 |
2010 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
This analysis is integrated with the literature on the roles of IFNgamma in mediating a plethora of functions: anti-microbial responses, antigen processing, inflammation, growth suppression, cell death, tumor immunity and autoimmunity.
|
20036577 |
2010 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity.
|
19077085 |
2009 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These infiltrating autoreactive T-cells and macrophages release inflammatory cytokines including interferon-gamma in the islets, not only damaging beta-cells but also accelerating CXCL10 generation in residual beta-cells and thus further activating cell-mediated autoimmunity until all beta-cells have been destroyed.
|
19641142 |
2009 |