|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Prostate carcinoma is highly dependent on the IGF/IGF-IR/IRS axis.
|
30338032 |
2018 |
|
Prostate carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
IGF1R is overexpressed by prostate cancer compared with benign prostatic epithelium and IGF1R expression commonly persists in androgen-independent metastatic disease at levels comparable to those in the primary.
|
12581018 |
2003 |
|
Prostate carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor-I receptor (IGF-IR) overexpression may play a role in prostate cancer progression.
|
19738069 |
2009 |
|
Prostate carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells.
|
23152410 |
2012 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor 1 receptor affects the survival of primary prostate cancer patients depending on TMPRSS2-ERG status.
|
28545426 |
2017 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IGF1R and AXL were identified as potential targets of miR-139 based on multiple miRNA-binding sites in 3'-untranslated regions of both the genes and their association with prostate cancer growth pathways.
|
31269290 |
2019 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Activation of epidermal growth factor receptor (EGFR), type 1 insulin-like growth factor receptor (IGF1R), and crosstalk between these two signaling pathways have been implicated in the development of radiation resistance in PC.
|
23950876 |
2013 |
|
Prostate carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Analysis of information from public gene expression databases confirmed that co-expression of insulin receptor mRNA and IGF-I receptor mRNA is common in prostate cancer specimens.
|
18785179 |
2009 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer.
|
19790231 |
2010 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study.
|
18726972 |
2009 |
|
Prostate carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Based on data from genome‑wide association study of the Consortium for Chinese Consortium for Prostate Cancer Genetics, rs1815009 and rs2684788 inside 3'UTR of insulin‑like growth factor 1 receptor (IGF1R) presented significant genotype distribution between PCa and control samples.
|
30365147 |
2019 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo.
|
26452103 |
2015 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Collectively, we proposed a novel model for an IDH1R132H-microRNAs-IGF1R regulatory axis, which might provide insight into the function of IDH1R132H in PCa development.
|
29331887 |
2018 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
RGD |
Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat.
|
18079205 |
2008 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer.
|
22495974 |
2012 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IGF2 mRNA but not IGF2 receptor mRNA expression was increased in patient samples during progression to castrate-resistant PC as was immunoreactivity to INSR and IGF1R antibodies.
|
23319492 |
2013 |
|
Prostate carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, an inverse correlation between BRCA1 and IGF-IR levels was observed in the androgen receptor (AR)-negative prostate cancer-derived P69 and M12 cell lines.
|
19223505 |
2009 |
|
Prostate carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, lycopene treatment enhanced the growth-inhibitory effect of docetaxel more effectively on DU145 cells with IGF-IR high expression than on those PCa cell lines with IGF-IR low expression.
|
21403837 |
2011 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In human PCa, the lowest IGF-IR immunoreactivity group tended to have the lowest body mass index in both normal and PCa epithelium.
|
18175332 |
2008 |
|
Prostate carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show that androgens up-regulate insulin-like growth factor-I receptor (IGF-IR) expression and sensitize prostate cancer cells to the biological effects of IGF-I.
|
15753383 |
2005 |
|
Prostate carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR).
|
11507082 |
2001 |
|
Prostate carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model.
|
15574769 |
2004 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Inhibition of the IGF-IR or the Src-ERK pathway should be considered, therefore, as an adjuvant therapy in prostate cancer.
|
17875736 |
2007 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone.
|
28447314 |
2017 |
|
Prostate carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
It is well known that Src tyrosine kinase, insulin-like growth factor 1 receptor (IGF-IR), and focal adhesion kinase (FAK) play important roles in prostate cancer (PrCa) development and progression.
|
27232975 |
2017 |