Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice.
|
28467789 |
2017 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the effect of obovatol on cognitive deficits in two separate AD models: (i) mice that received intracerebroventricular (i.c.v.) infusion of Aβ(1-42) (2.0 μg/mouse) and (ii) Tg2576 mice-expressing mutant human amyloid precursor protein (K670N, M671L).
|
22212065 |
2012 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that phenotypes for onset and rate of cognitive decline vary with PSEN1 and APP genes, suggesting a behavioral heterogeneity in ADAD.
|
31386938 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
The SUMO1-APP transgenics displayed normal APP processing but, at later ages, exhibited increased insoluble Aβ and plaque density accompanied by increased dendritic spine loss, more pronounced synaptic and cognitive deficits.
|
29217476 |
2018 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
An amyloid precursor protein (APP) A673T mutation was found to be protective against Alzheimer's disease (AD) and cognitive decline in the Icelandic population and to associate with decreased levels of plasma β-amyloid in a Finnish population-based cohort.
|
29807259 |
2018 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We previously found that a mutation in APP that prevents this caspase cleavage ameliorated synaptic loss and cognitive impairment in a murine AD model.
|
28261092 |
2017 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that the Arctic APP mutation is sufficient to cause amyloid deposition and cognitive dysfunction, and thus the TgAPParc mouse model provides a valuable tool to study the effect of the Arctic mutation in vivo without possible confounding effect of other APP mutations.
|
19329229 |
2011 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Deposition of amyloid-β (Aβ), the proteolytic product of the amyloid precursor protein (APP), might cause neurodegeneration and cognitive decline in Alzheimer's disease (AD).
|
29331876 |
2018 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, overexpression of wild-type BACE1, but not non-SUMOylated K501R mutant, facilitates senile plaque formation and aggravates the cognitive deficit seen in the APP/PS1 AD mouse model.
|
29581300 |
2018 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Amyloid beta (Aβ) peptides in extracellular Aβ plaques, produced from the amyloid precursor protein (APP) via sequential processing by β- and γ-secretases, impair hippocampal synaptic plasticity, and cause cognitive dysfunction in AD patients.
|
24684630 |
2014 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the most widely used transgenic AD models (overexpressing mutated forms of amyloid precursor protein, presenilin, and/or tau) do not demonstrate the degree of inflammation, neurodegeneration (particularly of the cholinergic system), and cognitive decline that is comparable with the human disease.
|
25025046 |
2014 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In vivo, the combination alleviated cognitive deficits in the acute Aβ25-35 peptide injection model and in the mouse mutant APP transgenic model.
|
25566747 |
2015 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
RGD |
Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aβ-related metabolism.
|
28455102 |
2017 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice.
|
12544850 |
2003 |
Impaired cognition
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However, viral knockdown of neuronal BDNF in the hippocampus of APP/PS1 mice (in the absence of BFCN loss) neither increased the level of Aβ nor caused cognitive deficits.
|
29520217 |
2018 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we discovered that protopanaxadiol derivative 1-(3,4-dimethoxyphenethyl)-3-(3-dehydroxyl-20(s)-protopanaxadiol-3β-yl)-urea (DDPU) effectively improved the activity of daily living (ADL) and cognitive deficits in APP/PS1 transgenic mice.
|
29197516 |
2018 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, APP/PS1 mice were used to investigate cognitive impairment and related pathologies.
|
29736217 |
2018 |
Impaired cognition
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Likewise, NOX activity and expression of the specific NOX subunit NOX4 were significantly increased in APP×PS1 mice in an age-dependent manner, and NOX activity and cognitive impairment shared a significant linear relationship.
|
21798347 |
2011 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effect of silibinin on β-secretase levels, Aβ enzymatic degradation, and oxidative stress in the brains of APP/PS1 mice with cognitive impairments.
|
31087219 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, in the water maze test, Y maze, and fear conditioning test, 5-HT6 antagonist SB271046 recovered the cognitive impairment of APP/PS1 mice.
|
28931427 |
2017 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice.
|
27861127 |
2017 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found a coding mutation (A673T) in the APP gene that protects against Alzheimer's disease and cognitive decline in the elderly without Alzheimer's disease.
|
22801501 |
2012 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the mechanisms that Aβ-blocked extracellular space (ECS) induces memory disorders in APP/PS1 transgenic mice and addressed whether red light (RL) at 630 nm rescues cognitive decline by reducing Aβ-disturbed flow of interstitial fluid (ISF).
|
31720368 |
2019 |
Impaired cognition
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Using a gene therapy approach, here we show that increasing brain p62 expression rescues cognitive deficits in APP/PS1 mice, a widely used animal model of AD.
|
27573878 |
2017 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Disorders associated with early-life alterations in amyloid precursor protein production or processing are associated with a distinct pattern of early striatal fibrillary Aβ deposition before significant cognitive impairment.
|
29477284 |
2018 |