Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
MGD |
|
|
|
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Gene dosage of the amyloid beta precursor protein in Alzheimer's disease.
|
2960019 |
1987 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Recently, it has been suggested that Alzheimer's disease is associated with a duplication of the amyloid precursor protein gene localized to chromosome 21q21.
|
2966761 |
1987 |
Alzheimer's Disease
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that APP gene expression is highly regulated in normal tissue, that many different cell classes in brain express the APP gene, and that neuronal expression may increase specifically in brain regions where widespread injury occurs in AD.
|
3063300 |
1988 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, the antibodies to the carboxyl terminus of beta APP labeled amyloid-containing senile plaques in AD brain.
|
3140239 |
1988 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
If this twofold increase in the APP-751 mRNA/APP-695 mRNA ratio results in a corresponding increase in the APP-751/APP-695 protein ratio, this would support the hypothesis that impaired proteolysis promotes the accumulation of abnormal proteins in the brain during AD.
|
2460367 |
1988 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Using an oligonucleotide probe, we isolated cDNA clones corresponding to the precursor of the beta-amyloid peptide (BAP) from brain libraries of 3 patients with sporadic Alzheimer's disease (AD).
|
3064874 |
1988 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
To study the putative precursor proteins (PreA4(695), PreA4(751), and PreA4(770] of Alzheimer's disease A4 amyloid protein, polyclonal and monoclonal antibodies were raised against a recombinant bacterial PreA4(695) fusion protein.
|
2649245 |
1989 |
Alzheimer's Disease
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Amyloid peptide precursor (APP) gene expression increases in the brains of patients with Alzheimer's disease (AD).
|
2510042 |
1989 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Understanding the processing of the beta-amyloid precursor protein and the origin of beta-amyloid deposits should provide insights into a potentially seminal feature of cortical degeneration in Alzheimer's disease.
|
2504258 |
1989 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Polypeptide (A4), which is derived from a larger precursor membrane protein (beta APP), is an important component of brain amyloid in Alzheimer's disease.
|
2505864 |
1989 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
The mRNAs for APP, HNFL, and alpha-tubulin were diminished in AD cortex.
|
2469380 |
1989 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Whereas in Down's syndrome, over-expression of the gene coding for PreA4 is likely to be responsible for the premature development of cerebral amyloidosis, a similar mechanism is yet to be demonstrated in Alzheimer's disease.
|
2569883 |
1989 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Sequence analysis of the various clones revealed 16 exons to encode the 695 residue precursor protein (PreA4(695] of Alzheimer's disease amyloid A4 protein.
|
2783775 |
1989 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
The regulation of extracellular proteolysis by PN-II and the deposition of at least parts of the molecule in senile plaques is consistent with previous reports that implicate altered proteolysis in the pathogenesis of Alzheimer's disease.
|
2507928 |
1989 |
Alzheimer's Disease
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
This cytokine is elevated in AD, its receptors are on APP mRNA positive cells and it promotes APP gene expression.
|
2510037 |
1989 |
Alzheimer's Disease
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
These observations indicate that processing of the beta APP changes in normal individuals as they age and to a greater extent in those who develop AD.
|
2113204 |
1990 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
The beta-amyloid protein (beta/A4), derived from a larger amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease.
|
1691865 |
1990 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
The beta-amyloid peptide is a core component of the neuritic plaques that accumulate in Alzheimer's disease.
|
2115911 |
1990 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
The amyloid forming beta-peptide of Alzheimer's disease is synthesized as part of a larger integral membrane precursor protein (beta APP) of which three alternatively spliced versions of 695, 751, and 770 amino acids have been described.
|
1968460 |
1990 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
In the present report, we demonstrate that a specific spliced form of mRNA that is transcribed from the APP gene and that lacks the beta/A4 sequence is elevated in the nucleus basalis, occipitotemporal cortex, and parahippocampal gyrus in Alzheimer's disease brain relative to controls.
|
2400606 |
1990 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Alternative splicing of the transcript encoding the beta-amyloid precursor protein (BAPP) of Alzheimer's disease produces multiple mRNA species.
|
2113083 |
1990 |
Alzheimer's Disease
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the differential expression of APP transcripts is not correlated with the deposition of amyloid in cases of AD and aged monkeys.
|
2106906 |
1990 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain.
|
1689572 |
1990 |