|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
MGD |
|
|
|
|
Dermatitis, Atopic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In contrast to normal donors T cells from donors with AD predominantly express mRNA for IL-4, IL-5, and only diminished levels for IFN-gamma and IL-12 upon stimulation with SEB and SEA.
|
7819740 |
1995 |
|
Dermatitis, Atopic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that although acute and chronic AD lesions are associated with increased activation of IL-4 and IL-5 genes, initiation of acute skin inflammation in AD is associated with a predominance of IL-4 expression whereas maintenance of chronic inflammation is predominantly associated with increased IL-5 expression and eosinophil infiltration.
|
8040343 |
1994 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
BEFREE |
The spontaneous expression of IL-4 mRNA in unstimulated cultures from children with atopic dermatitis supports the possibility that previous in vivo activation has occurred, and suggests that IL-4 production is increased in vivo in atopic dermatitis.
|
8082305 |
1994 |
|
Dermatitis, Atopic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Abnormal IL-4 gene expression by atopic dermatitis T lymphocytes is reflected in altered nuclear protein interactions with IL-4 transcriptional regulatory element.
|
8618052 |
1996 |
|
Dermatitis, Atopic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD).
|
9158100 |
1997 |
|
Dermatitis, Atopic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
IL-4 mRNA expression was increased in stimulated T cells of children with allergic asthma and atopic dermatitis, but not in those with non-allergic asthma as compared with healthy controls.
|
9199876 |
1997 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the role of potentially cross-reactive T cells in the pathogenesis of psoriasis, interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) responses of circulating T cells to these peptides were analysed by ELISPOT and RT-PCR in 14 psoriatic patients, 12 healthy individuals and six patients with atopic dermatitis (AD).
|
9201310 |
1997 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-4 mRNA was detected in OB and two other AD-derived cell lines by IL-4-specific reverse transcription-polymerase chain reaction.IgE was also produced by the OB cells.
|
9355960 |
1997 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Since the T allele was reported to be associated with increased IL4 gene promoter activity compared with the C allele, our data indicate that genetic differences in transcriptional activity of the IL4 gene influence AD predisposition, particularly in Japanese, because of a high frequency of the T allele.
|
9643293 |
1998 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the mRNA expression of the IL-4 receptor (IL-4Ralpha), IL-5Ralpha, GM-CSFRalpha, and IL-12Rbeta2 in biopsy specimens from acute and chronic AD lesions, uninvolved AD skin, normal skin, and psoriatic skin lesions.
|
9723668 |
1998 |
|
Dermatitis, Atopic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Finally, spontaneous mRNA expression of IL-4 in blood CD8+ CD45RO+ T cells isolated from AD-H patients was increased, as determined by reverse transcriptase-polymerase chain reaction.
|
9856820 |
1998 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Family studies on these infants have shown a link between atopic dermatitis and the genomic region 5q31 adjacent to the interleukin-4 gene cluster.
|
10480758 |
1999 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our approach was to identify polymorphisms within the promoter regions of IL-4 and test their association with atopic eczema.
|
11496248 |
2001 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the polymorphisms in the IL-4 gene and the IL-4 receptor alpha chain gene play no role in the development of atopic eczema in patients who have normal IgE productivity.
|
11678851 |
2001 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
BEFREE |
PBMC and acute skin lesions of patients with atopic dermatitis (AD) are characterized by increased IL-4 and IL-13, but decreased IFN-gamma production.
|
11751999 |
2002 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
CTD_human |
Azole derivatives, ketoconazole, itraconazole, miconazole, and nonazole terbinafine hydrochloride, and tolnaftate reduced interleukin-4 and interleukin-5 secretion without altering that of interferon-gamma and interleukin-2 in anti-CD3/CD28-stimulated T cells from both atopic dermatitis patients and normal donors.
|
11886533 |
2001 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis.
|
11886533 |
2001 |
|
Dermatitis, Atopic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Together, our present study indicates that AP-1 is over-activated by IL-4 in PBMC of the atopic patients with the higher IgE level, thereby implying that IL-4-induced over-activation of AP-1 might be one of pathogenic factors in atopic dermatitis.
|
11912010 |
2002 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To assess whether genetic variants of TXA2 receptor, IL-4 and IL-4R alpha genes relate to the elevation of serum immunoglobulin E levels in patients with atopic dermatitis (AD), we conducted an association study of genetic polymorphisms of TXA2 receptor (795C/T), IL-4 (-589C/T), and IL-4R alpha (Ile50Val) in a Japanese population (n = 789).
|
11922633 |
2002 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
BEFREE |
This is the first report to demonstrate that canine atopic dermatitis is associated with over-production of IL-4.
|
11994107 |
2002 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We report linkage (P < 0.005) to the - 590C/T polymorphism in the promoter of the IL-4 gene for the semiquantitative trait severity score of AD.
|
12190659 |
2002 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
CTD_human |
Interleukin-4 plus anti-CD40 increased intracellular cAMP by activating cAMP-synthesizing adenylate cyclase in surface IgE- B cells, and the increase was greater in the cells from atopic dermatitis patients than in those from normal donors.
|
12230500 |
2002 |
|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Ketoconazole suppresses interleukin-4 plus anti-CD40-induced IgE class switching in surface IgE negative B cells from patients with atopic dermatitis.
|
12230500 |
2002 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, the frequency of the interleukin-4Ralpha polymorphism C3223T and the interleukin-4 polymorphism C590T tended to be higher in extrinsic atopic dermatitis than in intrinsic atopic dermatitis.
|
12406333 |
2002 |