|
Abdominal Infection
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The serum IL-4 and IL-10 levels in pulmonary infection was higher and the serum IL-10 level in pulmonary infection was higher than those in incision infection and abdominal infection (P<0.05).
|
30675219 |
2019 |
|
Acquired Hypogammaglobulinemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of IL-4 and IL-10 gene promoter polymorphisms with common variable immunodeficiency.
|
19249119 |
2010 |
|
Acquired Hypogammaglobulinemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Modulation of the Interleukin-21 Pathway with Interleukin-4 Distinguishes Common Variable Immunodeficiency Patients with More Non-infectious Clinical Complications.
|
29103189 |
2018 |
|
Acquired Immunodeficiency Syndrome
|
0.020 |
GeneticVariation
|
group |
LHGDN |
Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression.
|
12944981 |
2003 |
|
Acquired Immunodeficiency Syndrome
|
0.020 |
Biomarker
|
group |
BEFREE |
We found a consistent profile of increased TNF alpha and decreased IFN gamma and IL4 in all three syndromes compared to AIDS patients without neurological disease.
|
7874388 |
1994 |
|
Active tuberculosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor- beta , and interleukin-4 mRNA levels.
|
17299718 |
2007 |
|
Active tuberculosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The F/B ratio was positively related to the detectable IL-1B in TB (R<sup>2</sup> = 0.97, P < 0.01) and to the IL-4 in LTBI (R<sup>2</sup> = 0.27, P < 0.05).
|
30620398 |
2019 |
|
Acute Chest Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
IFN-γ/IL-4, IFN-γ/IL-13, and TNF-α/IL-4 ratios as markers of Th1/Th2 ratio were significantly higher for the ACS-T2D group and ACS-IGT group as compared to that in the ACS-NGT group and control group (P < 0.05).
|
29970710 |
2018 |
|
Acute encephalopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cerebrospinal fluid levels of granzyme A were significantly higher, and those of TNF-α and IL-1RA were significantly lower in the AE group than in the cFS group; however, no significant differences in the levels of granzyme B, IFN-γ, IL-1β, IL-4, IL-6, IL-8, and IL-10 were observed between the 2 groups.
|
31709864 |
2020 |
|
Acute exacerbation of chronic obstructive airways disease
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
RESULTS IL-4 and IL-8 levels showed statistically significant differences among the 3 groups of patients (both P<0.001); IL-4 level was significantly lower, while IL-8 level was significantly higher in the AECOPD group and ACOS group than those in the asthma group (all P<0.05).
|
27501772 |
2016 |
|
Acute exacerbation of chronic obstructive airways disease
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The concentration of IL-4 and IL-13 in AECOPD group was higher than that in the controls (P < .05).
|
29752829 |
2018 |
|
Acute GVH disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The authors also demonstrated the presence of IL-4 and interferon(IFN)-gamma mRNA within the same skin biopsy specimen, suggesting that this case of aGVHD was mediated by both Th1 and Th2 cell type.
|
12499902 |
2002 |
|
Acute GVH disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here we evaluated whether IL-4 suppresses acute GVHD in the un-irradiated parent-into-F1 GVHD model with relevance to renal allograft rejection.
|
28359782 |
2017 |
|
Acute GVH disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
There is no difference in IL-4 gene expression between patients with or without aGVHD, but the concentration of IL-4 for patients with grade II-IV aGVHD decreased.
|
15852028 |
2005 |
|
Acute hepatitis
|
0.200 |
Biomarker
|
disease |
RGD |
Adenovirus-mediated gene transfer in rat liver of interleukin 4 but not interleukin 10 produces severe acute hepatitis.
|
9367542 |
1997 |
|
Acute infectious disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Despite the strong inflammatory pattern, IL-1Ra and IL-4 are also induced during the acute infection.
|
29768624 |
2018 |
|
Acute infectious disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Our findings identify a unique property of Vγ1<sup>+</sup>γδT cells as one dominant early producers of IL-4 upon CVB3 acute infection which is a key mediator to protect mice against acute myocarditis by modulating IFNγ-secreting T response.
|
27886550 |
2017 |
|
Acute leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Gene polymorphisms and febrile neutropenia in acute leukemia--no association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 are associated with the disease in Turkish patients: a preliminary study.
|
24819208 |
2014 |
|
Acute leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.
|
12660931 |
2003 |
|
Acute Lung Injury
|
0.200 |
Therapeutic
|
disease |
RGD |
A new technique of bronchial microsampling and proteomic analysis of epithelial lining fluid in a rat model of acute lung injury.
|
24681349 |
2014 |
|
Acute lymphocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The molecular manipulation of IL-4 to abrogate its proinflammatory activity has generated a novel and therapeutically promising cytokine for the treatment of high-risk ALL.
|
11157494 |
2001 |
|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Inhibitory anti-tumor effects of interleukin-4 on Philadelphia chromosome-positive acute lymphocytic leukemia and other hematopoietic malignancies.
|
1493472 |
1992 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of IL-27, IL-4, IL-17, and interferon (IFN)-γ in healthy subjects as well as patients with ACS, including stable angina pectoris (SA), unstable angina pectoris (UA), and acute myocardial infarction (AMI), were determined using an enzyme-linked immunosorbent assay.
|
30631648 |
2019 |
|
Acute myocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings identify a unique property of Vγ1<sup>+</sup>γδT cells as one dominant early producers of IL-4 upon CVB3 acute infection which is a key mediator to protect mice against acute myocarditis by modulating IFNγ-secreting T response.
|
27886550 |
2017 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Significant differences were found between patients with severe AP and those with mild or moderately severe AP in IFN-γ (P < 0.001), IL6 (P < 0.001), TNF-α (P = 0.002), GM-CSF (P < 0.001), IL4 (P = 0.002), IL1b (P = 0.017), and IL13 (P < 0.001) concentrations.
|
29517628 |
2018 |