|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we ask whether chronic IDO1 inhibition by 1-methyl-tryptophan (1-MT, added at 2g/L in the drinking water) or chronic inhibition of tryptophan 2, 3 dioxygenase (TDO2), another enzyme capable of converting tryptophan to kynurenine, by 680C91 (15mg/kg per os), can rescue LPS-induced (0.83mg/kg IP) anxiety and cognitive deficits.
|
31753057 |
2020 |
|
Metastatic urothelial carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Linrodostat mesylate (BMS-986205) - a selective, potent, oral IDO1 inhibitor - combined with nivolumab has demonstrated safety and preliminary evidence of clinical activity in metastatic urothelial carcinoma.
|
31823654 |
2020 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Resolution of arthritis was associated with increased numbers of regulatory T cells, which are induced in a sCD83-IDO-TGF-β dependent manner.
|
31001257 |
2019 |
|
Aspergillosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The role played by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which catalyzes the first and rate-limiting step of tryptophan catabolism along the kynurenine pathway, is increasingly being recognized, but whether and how genetic variation of IDO1 influences the risk of aspergillosis in susceptible patients is incompletely understood.
|
31134053 |
2019 |
|
Merkel cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Kaplan-Meier and log-rank tests showed that MCC with lower IDO1 expression in tumor cells and with lower TDO2 and AhR expressions in TME had better overall survival than otherwise (P = .043, .008, and .035, respectively); lower TDO2 expression in TME was also associated with longer disease-specific survival (P = .016).
|
30240768 |
2019 |
|
Cystic Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
By using human bronchial epithelial cells and PBMC from CF and HSCT patients, respectively, we could show that the <i>IDO1</i> polymorphisms appeared to down-modulate IDO1 expression and function in response to IFNγ or <i>Aspergillus</i> conidia, and to associate with an increased inflammatory response.
|
31134053 |
2019 |
|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
We show that an hCMV infection of hRPE cells blocks IDO1 and iNOS mediated antimicrobial defense mechanisms necessary for the control of <i>S. aureus</i> and <i>T. gondii</i>. hCMV also inhibits immune suppressive effector mechanisms in hRPE.
|
30781494 |
2019 |
|
Down Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using metabolic tracing assays, we show that overexpression of IFN receptors encoded on chromosome 21 contribute to enhanced IFN stimulation, thereby causing IDO1 overexpression and kynurenine overproduction in cells with T21.
|
31628327 |
2019 |
|
Shigella Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
This is the first study that underscores the direct implication of the NOD2-EGFR axis in IDO1 production and its crucial homeostatic contributions during shigellosis.
|
30615126 |
2019 |
|
Encephalitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that Ido1 deletion promotes seizures and neuropathogenesis during acute TMEV encephalitis.
|
30770561 |
2019 |
|
Hepatolenticular Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
For this reason, we investigate whether or not Kyn and IDO activity is potentially useful biomarkers in pediatric AIH.Between January 2016 and January 2017, children of AIH type-1 (AIH-1, n = 37), AIH type-2 with liver kidney microsome-1 autoantibodies (AIH-2-LKM-1, n = 8), and autoantibody-negative Wilsons Disease (WD, n = 8) and alpha-1 anti-trypsin deficiency (AATD, n = 10), were enrolled in a cross-sectional survey of Kyn and Trp levels and Kyn/Trp ratios (IDO activity) by HPLC, and neopterin levels by ELISA.The mean Kyn and mean Kyn/Trp ratios of AIH-1 with smooth muscle antigen (SMA) 1.85 μM and 27 μmole/mmole, and AIH-2-LKM-1; 1.7 μM and 28.6 μmole/mmole were lower than that of the WD; 2.2 μM p = 0.03 and 33 μmole/mmole p = 0.02 and of AATD; 2.3 μM, p = 0.02 and 55 μM, p = 0.001.
|
30666511 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gal-3-dependent nephroprotective and immunosuppressive effects of renal DCs was due to the IDO1-induced expansion of renal Tregs since either inhibition of IDO1 activity in TLR-2-primed DCs or depletion of Tregs completely diminished DCs-mediated attenuation of CDDP-induced AKI.
|
31534532 |
2019 |
|
Liver diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The stage of liver disease and grade of liver biopsies in AIH-1 patients negatively correlated with the Kyn/Trp ratios.The serum Kyn levels and Kyn/Trp ratio of AIH patients, within or below the normal range, indicate a trend of IDO activity lower than non-autoimmune WD or AATD.
|
30666511 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The higher expression level of IDO1 was identified in 4 out of 7 GC cell lines.
|
31315643 |
2019 |
|
Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic aberrations (TRAF7, KLF4, AKT1, and SMO) and the effects of genetic aberrations on the expression of inhibitory immune checkpoint molecules (PD-L1, IDO, and TDO2) in skull base meningiomas are still unclear.
|
31177425 |
2019 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we examine the expression of PD-L1 and indoleamine 2,3-dioxygenase (IDO1) as a diagnostic tool to distinguish type 2 AIP from other forms of pancreatitis and PDAC.
|
31135488 |
2019 |
|
Protein-Losing Enteropathies
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In conclusion, our study suggests that decreased serum tryptophan concentrations in dogs with PLE is associated with increased intestinal IDO-1 expression.
|
31181125 |
2019 |
|
Respiratory Syncytial Virus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Contribution of IDO to human respiratory syncytial virus infection.
|
31091352 |
2019 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Infected C57BL/6J mice up-regulated proinflammatory cytokines, Ido1, and genes encoding the enzymatic cascade responsible for QuinA production in the kynurenine pathway prior to the onset of seizures.
|
30770561 |
2019 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
IDO1 was inversely associated with IHD (odds ratio (OR) 0.96 per standard deviation, 95% confidence interval (CI) 0.93 to 1.00, p-value = 0.04), diabetes (OR 0.91, 95% CI 0.85 to 0.97) and prostate cancer (OR 0.96, 95% CI 0.93 to 0.99) with a directionally consistent estimate for stroke (OR 0.98, 95% CI 0.95 to 1.02) but not with blood pressure, or the other cancers considered.
|
31186442 |
2019 |
|
Epstein-Barr Virus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Host cell transcriptional changes in response to EBV infection classified tumors into two molecular subtypes based on patterns of IFN signature genes and immune checkpoint markers, such as PD-L1 and IDO1.
|
31481499 |
2019 |
|
Squamous cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the prognostic impact of IDO1/PD-L1 co-expression and its relationship with tumor-infiltrating lymphocytes (TILs) in primary lung squamous cell carcinoma (SCC).
|
30642449 |
2019 |
|
Myocardial Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
IDO1 might be a potential therapeutic target for IHD, diabetes and prostate cancer.
|
31186442 |
2019 |
|
Malignant neoplasm of anus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Whereas recent studies of IDO1 inhibitors have shown mixed results, this study suggests that patients with anal cancer with high IDO1 expression have dismal prognosis and may represent a patient population primed for response to targeted IDO1 inhibition.
|
30755500 |
2019 |
|
Acute intermittent porphyria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with type 2 AIP showed pancreatic ductal staining for PD-L1 and IDO1 in 69% (24/35) and 60% (15/25) of cases, respectively.
|
31135488 |
2019 |