|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Methods</b>: In the present study, we developed an injectable PEG-<i>b</i>-poly(L-alanine) hydrogel for co-delivery of a tumor vaccine and dual immune checkpoint inhibitors to increase tumor immunotherapy efficacy.
|
31149045 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>In vivo</i>, ADI-PEG 20 induced tumor T-cell infiltration in a poorly immunogenic syngeneic mouse melanoma B16-F10 model and reduced its growth as a single agent or when combined with anti-PD-1 mAb.
|
28938609 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor growth in those animals was almost completely inhibited by treatment with Fa-PEG-g-PEI-SPION/psiRNA-TBLR1.
|
26680504 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Glycodelin mRNA was expressed in 68 patients (25%), more frequently in premenopausal women (P = 0.01) and those with HER2 mRNA-positive tumors (P = 0.02).
|
16823513 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PEG modification efficiently delivered TS shRNA in the lipoplex to tumor tissue following intravenous administration as indicated by a significant suppression of TS expression level in tumor tissue.
|
27740765 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PEG modification endowed the dye FEB-2000 with both long circulating times and good tumour targeting properties in a MDA-MB-231 xenograft model.
|
28989666 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PEG-coumarin nanoaggregates as π-π stacking derived small molecule lipophile containing self-assemblies for anti-tumour drug delivery.
|
29271302 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Glycodelin expression correlated between primary tumor and distant metastases within the same patients.
|
30518088 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PEG-M49 and Peg-Dox co-treatment induced complete tumor regression and loss of macroscopic lung metastasis in four out of seven WT mice.
|
31811336 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A combination cancer therapy was investigated via co-delivery of therapeutic gene encoding human tumor necrosis factor-related apoptosis-inducing ligand (pORF-hTRAIL) and doxorubicin (DOX) using a tumor-targeting carrier, peptide HAIYPRH (T7)-conjugated polyethylene glycol-modified polyamidoamine dendrimer (PAMAM-PEG-T7).
|
20971503 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A much higher accumulation of the MNPs@A54-PEG-g-p(AAm-co-AN) to the tumor navigated by the A54 targeting peptide is achieved.
|
28376364 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A SERRS/MRI multimodal contrast agent based on naked Au nanoparticles functionalized with a Gd(iii) loaded PEG polymer for tumor imaging and localized hyperthermia.
|
29292448 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accumulation efficiency of FA-PEG-COL nanoparticles was investigated in BALB/c mice bearing OVK18 #2 tumor xenograft using in vivo imaging.
|
24178005 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After self-assembly by using DPAHB with PEG-PLGA, the as-prepared nanovesicles (DPAHB NVs) retain efficient <sup>1</sup>O<sub>2</sub> generation, more interestingly, show high photothermal conversion efficiency (∼0.24) under NIR light (721 nm) irradiation for synergistic photodynamic therapy (PDT) and photothermal therapy toward hypoxic tumor.
|
30243149 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After the immigration of AuNR-P(AAm-<i>co</i>-AN-<i>co</i>-TPP)-<i>b</i>-PEG nanoparticles into the tumor tissue and the internalization by cancer cells, the UCST polymer chains can be extended under the local heating of <b>AuNRs</b> by NIR light irradiation, and then porphyrin photosensitizers are turned "On" to dramatically boost the PDT efficiency.
|
31490661 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Afterwards, the PEG shell is deshielded from the S-NP at the tumor tissue, resulting in improved cell uptake, enlarged MR signal intensity, rapid release of Ce6 within tumor cells, and elevated PDT efficacy.
|
28435466 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Almost 70% of administrated 20-nm magnetic nanoparticles still circulated in the blood stream after four hours; however, their retention in the tumor was rather low, which was likely due to the antifouling properties of PEG.
|
31341232 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although the fluorescence was successfully quenched, in vivo imaging with the quenched substrate CBG-800-PEG-QC1 failed to visualize the SNAP(f)-ADRβ2 expressing tumor, possibly due to the reduced reaction rate.
|
22479502 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An optimised 5FU-loaded formulation containing PEG as part of a block copolymer induced a pronounced reduction in tumour volume and tumour weight, together with an improved percentage tumour growth inhibition.
|
29857301 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Arginine depletion with pegylated arginine deiminase (ADI-PEG 20) dramatically suppresses tumor growth and promotes survival of mice specifically with MYC-driven tumors, including in GEMMs, human cell line xenografts, and a patient-derived xenograft from a relapsed patient.
|
31164374 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on it, this paper builds HES-TG100-115-CDM-PEG micelles with tumor microenvironment responsiveness that simultaneously loaded sorafenib and TG100-115 to synergistically treat liver cancer.
|
31357893 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on the r<sub>1</sub> and r<sub>2</sub> relaxivity obtained from the MnS core and the strong near-infrared absorption and X-ray attenuation abilities of the Bi<sub>2</sub>S<sub>3</sub> shell, the intratumoral injected MnS@Bi<sub>2</sub>S<sub>3</sub>-PEG can realize in vivo magnetic resonance, computer tomography, and photoacoustic tumor imaging under a single injection dose.
|
28696454 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier.
|
20537703 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both [<sup>64</sup>Cu]-DOTHA<sub>2</sub>-PEG-RM26 and [<sup>64</sup>Cu]-NOTA-PEG-RM26 displayed similar tumor and normal tissue uptakes at early time point post injection.
|
29154145 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By controlling the size and complexity of PEG molecules, as well as by attaching targeting moieties, the surface characteristics of NPs can be manipulated to improve their tumor uptake without sacrificing the circulation time.
|
30062957 |
2018 |