|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We examined the association between COX-2 and DCAMKL1 expression in gastric carcinomas in clinical samples (early gastric well-differentiated adenocarcinoma) and Cdx2-transgenic mice; and the DCAMKL1-transgenic mouse stomach using immunohistochemistry and quantitative real-time polymerase chain reaction.
|
25228975 |
2014 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Keratins 8, 19, and 20 as well as carbonic anhydrases (II, IV, VII) showed side specific expression and were downregulated in left sided tumours whereas teratocarcinoma growth factor and cyclooxygenase 2 (COX-2) were upregulated in left sided adenocarcinomas.
|
15710986 |
2005 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
There was also a higher prevalence of microsatellite instability-high tumours and low Cox-2 expression in colorectal SRCC as opposed to conventional adenocarcinoma.
|
20686774 |
2011 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In the present study, we found elevated expression of COX-2 and FP receptor colocalized together within the neoplastic epithelial cells of endometrial adenocarcinomas.
|
16081631 |
2005 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
COX-2 was expressed in 14.3% of normal gallbladder epithelium, 70.3% of dysplastic epite hlium, and 59.2% of adenocarcinomas.
|
16733863 |
2006 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
COX-1 and COX-2 expression in adenocarcinoma cell lines was determined using reverse transcription-PCR and Western blotting for mRNA and protein, respectively.
|
11059772 |
2000 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that an increase in COX-2 expression may be associated with the development of adenocarcinomas and possibly with acquisition of an invasive and metastatic phenotype.
|
9731479 |
1998 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The presence of oncogenic K-ras did not correlate with the level of COX-2 protein expressed in the pancreatic adenocarcinomas analyzed.
|
10657949 |
2000 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Differences between the levels of expression of COX-2 in primary tumors and their corresponding metastatic lymph nodes in 9 adenocarcinoma patients were not significant.
|
10665651 |
1999 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Cyclooxygenase-2 expression in human adenocarcinoma cell line HT29 cl.19A.
|
9703885 |
1998 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Higher Cox-2 expression might be associated with tumor progression and worse prognosis through EGFR signaling interaction in Stage I bronchial adenocarcinomas.
|
15246187 |
2004 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We hypothesized that acid-induced activation of the MAPK pathways mediates an increase in COX-2 expression in Barrett's esophagus, and we tested this hypothesis in a Barrett's-associated adenocarcinoma cell line (SEG-1).
|
15231484 |
2004 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Aspirin could down-regulate the strong expression of cyclooxygenase-2 in the tissue of gastric adenocarcinomas of nude mice.
|
12781040 |
2003 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The purpose of this study was to investigate Cox-2 protein expression in human gastric dysplasias and adenocarcinomas.
|
11448905 |
2001 |
|
Adenocarcinoma
|
0.600 |
Biomarker
|
group |
BEFREE |
Our data suggest that in addition to COX-2, EP2 and EP4 receptors could be a selective target in the prevention and/or treatment of the Barrett's-associated adenocarcinoma.
|
19843025 |
2010 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In this study, immunohistochemical analysis of 29 Barrett's epithelial samples and 60 esophageal adenocarcinomas demonstrated abundant expression of the COX-2 protein in Barrett's epithelium, but marked heterogeneity of expression in esophageal adenocarcinomas.
|
11005569 |
2001 |
|
Adenocarcinoma
|
0.600 |
Biomarker
|
group |
BEFREE |
Moreover, immunohistochemical analysis using serial sections of human colon adenocarcinomas revealed a strong positive correlation between COX-2 and FasL (r=0.722; P<0.0001) expression, and between EP1 receptor and FasL (r=0.740; P<0.0001) expression, in the tumour cells.
|
18648368 |
2008 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We therefore investigated a possible relationship between cytoplasmic PLA2 and COX-2 overexpression in stromal cells, angiogenesis and microsatellite instability in 48 human colorectal adenocarcinomas.
|
15475936 |
2005 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Expression of the Cox-2 protein was also seen in all 11 squamous cell carcinomas studied, although the level of staining seemed to be less than that in the adenocarcinomas.
|
9823297 |
1998 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that an increase in COX-2 expression may be clinically significant for the prognosis of patients undergoing surgical resection of early-stage adenocarcinomas and, thus, warrant further conclusive studies involving a larger cohort.
|
10353732 |
1999 |
|
Adenocarcinoma
|
0.600 |
Biomarker
|
group |
BEFREE |
The aim of this study was to evaluate cyclooxygenase-2 (COX-2) immunoreactivity in colorectal adenocarcinomas and to find correlations with different pathological features.
|
25169526 |
2014 |
|
Adenocarcinoma
|
0.600 |
Biomarker
|
group |
BEFREE |
A longitudinal case-control study compared COX-2 in patients who progressed to adenocarcinoma with nonprogressors matched for age and length of follow-up.
|
15269153 |
2004 |
|
Adenocarcinoma
|
0.600 |
Biomarker
|
group |
BEFREE |
COX-2, the inducible isoenzyme, was found to be overexpressed in approximately 85% of colorectal adenocarcinomas, contributing to key steps in tumor development.
|
20075740 |
2010 |
|
Adenocarcinoma
|
0.600 |
Biomarker
|
group |
BEFREE |
Long-term COX-2 inhibition markedly reduced adenocarcinoma formation, as well as angiogenesis in a mouse model of prostate-specific PKCε expression and Pten loss.
|
29765153 |
2018 |
|
Adenocarcinoma
|
0.600 |
AlteredExpression
|
group |
BEFREE |
COX-2 RNA expression was confirmed in various grades of adenocarcinoma by ribonuclease protection assay.
|
11592775 |
2001 |