|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among lymphomas, IgH monoclonality was detected in 7 (77%) of 9 NHLs and BCL2 rearrangement in 3 (17.6%) of 17 NHLs, all of which were follicular centroblastic-centrocytic (FCBCC).
|
9276187 |
1997 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
BEFREE |
NHL is commoner in men than in women, and our data indicate a trend toward higher bcl2 mutagenesis in males than females.
|
9020305 |
1997 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
BEFREE |
BCL-2 antisense therapy in patients with non-Hodgkin lymphoma.
|
9113013 |
1997 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
BEFREE |
The first member of this gene family to be identified was BCL-2, by virtue of its involvement in t(14;18) chromosomal translocations commonly found in B-cell non-Hodgkin's lymphoma (NHL).
|
9408956 |
1997 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Other studies have suggested an inverse relationship between p53 and bcl-2 protein expression in breast and colonic cancers and in a variety of subtypes of non-Hodgkin's lymphoma.
|
9349233 |
1997 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study.
|
8704213 |
1996 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Preservation of functional and regulatory domains of expressed bcl-2 genes in non-Hodgkin's lymphoma.
|
8558921 |
1996 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sequence preservation of the third exon of the bcl-2 gene in non-Hodgkin's lymphoma: absence of somatic hypermutation.
|
7723399 |
1995 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocations and amplification of the BCL2 gene are detected in interphase nuclei of non-Hodgkin's lymphoma by in situ hybridization with yeast artificial chromosome clones.
|
7632955 |
1995 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Antisense oligodeoxyribonucleotide down-regulation of bcl-2 gene expression inhibits growth of the low-grade non-Hodgkin's lymphoma cell line WSU-FSCCL.
|
8528964 |
1995 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that bcl-2 gene deregulation, but not the precise moment at which this occurs during the pre-B-cell stage, influences the development of follicular NHL.
|
8555066 |
1995 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines.
|
8574164 |
1995 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Clinical significance of bcl-2-MBR gene rearrangement and protein expression in diffuse large-cell non-Hodgkin's lymphoma: an analysis of 83 cases.
|
8270971 |
1994 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cumulative poor effect of both p53 and bcl-2 in large B-cell lymphomas, which is more significant in nodal tumours, could confirm the existence of a multistep genetic deregulation in non-Hodgkin's lymphoma.
|
8297731 |
1994 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interestingly these fragile sites were located in the same chromosomal bands as the oncogenes, MOS, MYC, BCL-1 and BCL-2 as well as cancer breakpoints specifically associated with non-Hodgkin's lymphoma, suggesting the possibility that fragile sites may play a critical role in the pathogenesis of non-Hodgkin's lymphoma.
|
7954347 |
1994 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Twenty cases of Japanese non-Hodgkin's lymphoma with B cell markers were studied with respect to their immunoglobulin heavy (IgH) chain gene loci on chromosome 14 and BCL2 loci on chromosome 18.
|
1747446 |
1991 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
BEFREE |
Twenty-nine cases of non-Hodgkin's lymphoma of low-grade malignancy in a European population were investigated for the presence of bcl-2 and bcl-1 gene rearrangement.
|
1757070 |
1991 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Establishment and characterization of a new human B-cell line (ONHL-1) from non-Hodgkin's lymphoma: constant expression of bcl-2 gene during mitogen-induced growth inhibition.
|
2249898 |
1990 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sequential bcl-2 and c-myc oncogene rearrangements associated with the clinical transformation of non-Hodgkin's lymphoma.
|
2509518 |
1989 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation.
|
3287162 |
1988 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Southern blotting was used to detect rearrangement of the bcl-2 gene in 104 cases of non-Hodgkin's lymphoma subclassified by the Working Formulation, 24 cases of B cell chronic lymphocytic leukemia (B-CLL) and 14 cases of T cell malignancy.
|
2965608 |
1988 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.400 |
Biomarker
|
disease |
CTD_human |
Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation.
|
3287162 |
1988 |