SLC2A4, solute carrier family 2 member 4, 6517

N. diseases: 158; N. variants: 7
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression. 17035674 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE Type 2 diabetes mellitus and obesity are associated with impaired regulation of GLUT4 gene expression and elevated levels of free fatty acids and proinflammatory factors. 17317207 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease BEFREE In conclusion, our data demonstrate that GLUT4 is present in the endometrium of normal and PCOS subjects and that hyperinsulinism and obesity seem to have a negative effect on endometrial GLUT4 expression in PCOS. 15292352 2004
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE The similar results in lean PCOS and control subjects suggest that endometrial GLUT4 expression is not affected by PCOS itself, whereas it is reduced by obesity in PCOS patients. 15731326 2004
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE GLUT4 expression is up-regulated by exercise training and thyroid hormone treatment and is down-regulated by fasting, streptozotocin-induced diabetes, obesity, high-fat diet, and denervation. 9405224 1997
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE We report that expression of GLUT-4 is reduced in NIDDM and in obesity associated with hyperinsulinemia and insulin resistance. 7868815 1994
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE Skeletal muscle GLUT 4 expression is normal in obesity, impaired glucose tolerance (IGT), GDM, and NIDDM, indicating that functional activity or translocation of GLUT 4 may be impaired.4. 8087095 1994
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease BEFREE To gain insight into the molecular pathogenesis of obesity and specifically the role of nutrient partitioning in the development of obesity, we overexpressed the insulin-responsive glucose transporter (GLUT4) in transgenic mice under the control of the fat-specific aP2 fatty acid-binding protein promoter/enhancer. 8226728 1993
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE Levels of GLUT4 mRNA were similarly not affected by obesity, IGT, or NIDDM whether normalized per RNA or for the amount of an unrelated constitutive mRNA species. 1535055 1992
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease BEFREE Relative to lean controls, the cellular content of GLUT 4 was decreased 40% in obesity and 85% in NIDDM in total cellular membranes. 1999488 1991
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. 2354749 1990