SNCA, synuclein alpha, 6622

N. diseases: 36; N. variants: 44
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1868595
Disease: PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder)
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C1868595
Disease: PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder)
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.900 Biomarker disease CTD_human
CUI: C1868595
Disease: PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder)
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C1854182
Disease: PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder)
PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder) 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C1854182
Disease: PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder)
PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder) 		0.700 Biomarker disease CTD_human
CUI: C1854182
Disease: PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder)
PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder) 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C1854182
Disease: PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder)
PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder) 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C0677050
Disease: Manganese Poisoning
Manganese Poisoning 		0.300 Biomarker disease CTD_human α-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. 23934647 2014
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.700 Biomarker disease CTD_human Alpha-synuclein is a lipid-binding protein expressed in neurons and oligodendrocytes which is increased in Parkinson's disease. 18841091 2008
CUI: C1868595
Disease: PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder)
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.900 GeneticVariation disease UNIPROT A novel α-synuclein missense mutation in Parkinson disease. 23427326 2013
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.400 Biomarker group CTD_human A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. 22430071 2012
CUI: C0270715
Disease: Degenerative Diseases, Central Nervous System
Degenerative Diseases, Central Nervous System 		0.300 Biomarker group CTD_human A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. 22430071 2012
CUI: C0751733
Disease: Degenerative Diseases, Spinal Cord
Degenerative Diseases, Spinal Cord 		0.300 Biomarker group CTD_human A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. 22430071 2012
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.400 Biomarker group CTD_human Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. 18514411 2008
CUI: C0270715
Disease: Degenerative Diseases, Central Nervous System
Degenerative Diseases, Central Nervous System 		0.300 Biomarker group CTD_human Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. 18514411 2008
CUI: C0751733
Disease: Degenerative Diseases, Spinal Cord
Degenerative Diseases, Spinal Cord 		0.300 Biomarker group CTD_human Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. 18514411 2008
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.400 Biomarker group CTD_human Adult-onset neurodegeneration with brain iron accumulation and cortical alpha-synuclein and tau pathology: a distinct clinicopathological entity. 17296847 2007
CUI: C0270715
Disease: Degenerative Diseases, Central Nervous System
Degenerative Diseases, Central Nervous System 		0.300 Biomarker group CTD_human Adult-onset neurodegeneration with brain iron accumulation and cortical alpha-synuclein and tau pathology: a distinct clinicopathological entity. 17296847 2007
CUI: C0751733
Disease: Degenerative Diseases, Spinal Cord
Degenerative Diseases, Spinal Cord 		0.300 Biomarker group CTD_human Adult-onset neurodegeneration with brain iron accumulation and cortical alpha-synuclein and tau pathology: a distinct clinicopathological entity. 17296847 2007
CUI: C1868595
Disease: PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder)
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.900 GeneticVariation disease UNIPROT Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. 9462735 1998
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.580 Biomarker disease CTD_human Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers. 18055133 2008
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.330 Biomarker disease CTD_human Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers. 18055133 2008
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.320 Biomarker disease CTD_human Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers. 18055133 2008