Crohn Disease
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis.
|
18500230 |
2008 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the adaptive immune response, IL23R, MST1, IL12B, and STAT3 polymorphisms are associated with Crohn's disease and ulcerative colitis.
|
19647622 |
2009 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies indicate that IL23R and five additional genes involved in Th17 differentiation (IL12B, JAK2, STAT3, CCR6 and TNFSF15) are associated with susceptibility to Crohn's disease and partly also to ulcerative colitis.
|
19592695 |
2009 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The originally described association of IBD with STAT3 polymorphisms is corroborated for the two clinical phenotypes, CD and UC, in an independent population.
|
20200543 |
2010 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Two members of that pathway, STAT3 and JAK2, enhanced the risk of Crohn's disease (CD) in recent genome-wide association studies.
|
20109474 |
2010 |
Crohn Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In addition, triptolide (20ng/ml) in vitro was able to down-regulate the IL-6/STAT3 pathway and reduce IL-17 expression in cultured colonic explants from patients with Crohn's disease (CD).
|
20615550 |
2010 |
Crohn Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Of CD susceptibility genes identified by genome-wide association scan IL-23A, JAK2, and STAT3 were upregulated in the CD group, confirming the dysregulation of Th17 signaling.
|
20848455 |
2010 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01).
|
20222910 |
2010 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The protective haplotype for MS in STAT3 is a risk allele for Crohn disease, implying that STAT3 represents a shared risk locus for at least two autoimmune diseases.
|
20159113 |
2010 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease.
|
21152001 |
2010 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We recruited 369 AJ CD patients and 503 AJ controls, genotyped 22 single nucleotide polymorphisms (SNPs) at or near 10 CD-associated genes, NOD2, IL23R, IRGM, ATG16L1, PTGER4, NKX2-3, IL12B, PTPN2, TNFSF15 and STAT3, and assessed their association with CD status.
|
21548950 |
2011 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.
|
22065112 |
2012 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Colonic expression of genes regulating STAT3 signaling and leukocyte recruitment and function was measured in pediatric patients with Crohn disease (CD) stratified by STAT3 genotype.
|
22197944 |
2012 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Data on genetic interaction reveals that the above JAK2 and STAT3 risk alleles contribute to CD susceptibility in combination with each other (OR: 2.218; 95% CI: 1.097-4.487; P = 0.024), while the JAK2 variant shows a tendency to confer UC risk only on a wild-type STAT3 background (OR: 1.997, 95%CI: 0.994-4.009, P = 0.049).
|
22269120 |
2012 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DNA was tested for three CD-associated NOD2 variants (3020insC, G908R, R702W), variants in IRGM, ATG16L1, IL12B, IL23R, STAT3, and a TLR5-stop mutation.
|
22275320 |
2012 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Other than genetic variants of IL-10 receptors, IL-10 and STAT3 genes are also associated with IBD, emphasizing the involvement of the IL-10 signalling cascade in the pathogenesis of CD and UC.
|
21631466 |
2012 |
Crohn Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Elevated plasma IL-6 levels were detected in CD (P = 0.004), which strongly correlated with disease activity (ρ = 0.690, P<0.001) but not with IL-6-induced STAT3 phosphorylation.
|
23950992 |
2013 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-6/STAT3/SOCS3 signaling pathway plays an important role in the pathogenesis of Crohn's disease by induction of the antiapoptotic factors Bcl-2 and Bcl-xl in lamina propria mononuclear cells (LPMCs).
|
23643741 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10(-59)), TNFSF15 (rs6478106, P = 3.87 × 10(-45)), and STAT3 (rs9891119, P = 2.24 × 10(-14)).
|
23266558 |
2013 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study does not support the role of the TYK2 and STAT3 genes influencing CD susceptibility.
|
23408403 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
|
23266558 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
|
23266558 |
2013 |