ZEB1, zinc finger E-box binding homeobox 1, 6935

N. diseases: 310; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.010 Biomarker disease BEFREE Furthermore, the expressions of miR-590-3p and ZEB1 were identified in infarct area of MI model in pigs. 31675172 2020
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus
0.010 AlteredExpression disease BEFREE Dysplastic BE tissues also had significantly increased levels of ZEB1 and significantly decreased levels of CDH1 compared with nondysplastic BE tissues. 30268789 2019
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.010 Biomarker disease BEFREE ZEB1 and JUN were both found to be involved in the role of miR-429 in RCC. 31550675 2019
CUI: C0009319
Disease: Colitis
Colitis
0.010 Biomarker disease BEFREE ZEB1 was induced in the colonic epithelium of UC and of mouse models of colitis. 31366457 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.010 Biomarker disease BEFREE ZEB1 was induced in the colonic epithelium of UC and of mouse models of colitis. 31366457 2019
CUI: C0014869
Disease: Peptic Esophagitis
Peptic Esophagitis
0.010 AlteredExpression disease BEFREE Columnar-lined esophagus of rats with reflux esophagitis had increased expression of ZEB1/2 and decreased expression of CDH1 compared with controls. 30268789 2019
CUI: C0018081
Disease: Gonorrhea
Gonorrhea
0.010 AlteredExpression disease BEFREE CONCLUSIONS ZEB1 expression is increased in GC tumor tissues and is associated with pathological features. 30829316 2019
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.010 Biomarker disease BEFREE Quantitative stable isotope labeling by amino acids in cell culture (SILAC) proteomics was used to elucidate the effect of elevated ZEB1, as noted during hyperglycemia. 31439646 2019
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.010 Biomarker disease BEFREE The findings of this study suggest inclusion of SNAI1 and ZEB1 genes expression in the cluster of potential genetic biomarkers to be studied in AML cases as diagnostic and prognostic markers. 31055699 2019
CUI: C0023646
Disease: Lichen Planus
Lichen Planus
0.010 Biomarker disease BEFREE TWIST1 and ZEB1 stainings were negative in the epithelium in both lichen planus and controls. 31228209 2019
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.010 AlteredExpression group BEFREE Numerous studies have demonstrated that abnormal expression of ZEB1 in many types of liver disease including hepatocellular carcinoma (HCC). 31712061 2019
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.010 Biomarker disease BEFREE Knockdown of Zeb1 can attenuate Nodal-induced malignancy of NB cells. 30985990 2019
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.010 AlteredExpression disease BEFREE In conclusion, these findings suggest that XIST may facilitate the progression of RB through acting as a ceRNA for miR-101 to mediate the expression of ZEB1 and ZEB2. 30472203 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.010 GeneticVariation disease BEFREE The schizophrenia associated ZEB1 gene encodes a transcription factor susceptible to transcriptional control by a hypoxia induced factor, HIF1A, known to be implicated in blood-brain barrier dysfunction. 30144413 2019
CUI: C0206139
Disease: Lichen Planus, Oral
Lichen Planus, Oral
0.010 Biomarker disease BEFREE Based on the present study, the role of TWIST1 and ZEB1 in oral lichen planus remains unclear. 31228209 2019
CUI: C0259785
Disease: Malignant Meningioma
Malignant Meningioma
0.010 Biomarker disease BEFREE Bioinformatics analysis and mechanism experiments demonstrated that LINC00702 acted as the molecular sponge of miR-4652-3p to upregulate ZEB1 in malignant meningioma. 30849635 2019
Schnyder crystalline corneal dystrophy
0.010 Biomarker disease BEFREE The clinical findings suggested co-occurrence of PPCD3 and Schnyder corneal dystrophy in the proband. 30950897 2019
Metastatic non-small cell lung cancer
0.010 Biomarker disease BEFREE Here we apply two independent screens, BioID and an Epigenome shRNA dropout screen, to define ZEB1 interactors that are critical to metastatic NSCLC. 31719531 2019
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm
0.010 Biomarker phenotype BEFREE Therefore, we performed the present meta-analysis to evaluate the prognostic value of ZEB-1 in patients with solid tumors. 31248382 2019
CUI: C0280324
Disease: Laryngeal Squamous Cell Carcinoma
Laryngeal Squamous Cell Carcinoma
0.010 AlteredExpression disease BEFREE A secondary end-point was to conduct a preliminary clinical and pathological investigation into the possible role of β-arrestin-1 in the epithelial-to-mesenchymal transition (EMT), identified by testing for E-cadherin, Zeb1, and Zeb2 expression, in the setting of LSCC. 30854928 2019
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.010 Biomarker disease BEFREE Since <i>SNAIL-1</i>, <i>Twist</i>, and <i>ZEB-1</i> have been shown to be overexpressed in MM, these genes could be considered possible predictive or diagnostic markers of MM development. 30609805 2019
CUI: C0410158
Disease: Muscle damage
Muscle damage
0.010 PosttranslationalModification phenotype BEFREE Macrophages in Zeb1-deficient injured muscles show lower phosphorylation of p38 and its forced activation reverts the enhanced muscle damage and poorer regeneration. 30910999 2019
CUI: C0521607
Disease: Peritoneal Fibrosis
Peritoneal Fibrosis
0.010 Biomarker disease BEFREE Furthermore, we demonstrated that miR-200a inhibition of PF in vivo was associated with the suppression of ZEB1 and 2, which were proved to be the target of miR-200a in our previous study. 30888602 2019
CUI: C0553723
Disease: Squamous cell carcinoma of skin
Squamous cell carcinoma of skin
0.010 AlteredExpression disease BEFREE Silencing of EPHB2 in the human cSCC cell line A431 induced epithelial-mesenchymal transition (EMT)-like morphological changes accompanied by a significant upregulation of epithelial-mesenchymal transition-associated genes such as zinc finger E-box binding homeobox 1/2. 30881495 2019
Gastro-esophageal reflux disease with esophagitis
0.010 AlteredExpression disease BEFREE Columnar-lined esophagus of rats with reflux esophagitis had increased expression of ZEB1/2 and decreased expression of CDH1 compared with controls. 30268789 2019