|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that PACAP is not involved in the regulation of expression of TH in neuroblastomas.
|
15518890 |
2004 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
BM aspirates, trephine biopsies, PB, and peripheral blood stem cell (PBSC) samples from Italian children with neuroblastoma were analyzed by morphological and histologic techniques, as well as by immunocytochemistry (IC) for disialoganglioside GD(2) and reverse transcription-PCRs (RT-PCRs) for tyrosine hydroxylase (TH) and pgp9.5 genes.
|
15585633 |
2004 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, THp was chosen for a neuroblastoma-selective suicide gene therapy approach using the herpes simplex virus type 1 thymidine kinase (HSV-tk)/ganciclovir (GCV) system.
|
15181182 |
2004 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Based on these results, the detection of TH mRNA is very useful both as a tumor marker for NB and for detecting minimal residual disease.
|
14993794 |
2004 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We demonstrate the induction of protective immunity against syngeneic murine NXS2 neuroblastoma in A/J mice following vaccination with tyrosine hydroxylase (TH)-derived antigens.
|
15650237 |
2004 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A causal link between the transformed phenotype and MYCN has been established by a range of in vitro and in vivo studies, including a transgenic model of neuroblastoma in which MYCN overexpression is targeted to neuronal tissue by the use of a tyrosine hydroxylase promoter.
|
12880971 |
2003 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
The described TH assay is specific, sensitive, and semiquantitative and can be used for the detection of neuroblastoma cell involvement in bone marrow and blood at diagnosis and during therapy.
|
12576454 |
2003 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The described TH assay is specific, sensitive, and semiquantitative and can be used for the detection of neuroblastoma cell involvement in bone marrow and blood at diagnosis and during therapy.
|
12576454 |
2003 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Quantitative analysis of tyrosine hydroxylase mRNA in blood and bone marrow is reliable and easy to perform and may be used for upfront staging, prognostic assessment, and treatment monitoring of neuroblastoma.
|
12507966 |
2003 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of the tyrosine hydroxylase gene (TH) is regulated in a tissue-specific manner during neonatal development and differentiation, therefore TH mRNA expression is a specific tumour marker for NB.
|
12579272 |
2003 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Flow cytometry (FCM) with CD45/CD56/CD81 and reverse transcriptase-polymerase chain reactions (RT-PCR) for tyrosine hydroxylase (TH) transcripts were used to evaluate neuroblastoma in bilateral BM aspirates at diagnosis, BM autografts, peripheral blood stem cell (PBSC) collections, and CD34(+) cell products of 27 children.
|
12767104 |
2003 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that etoposide can be designed as a prodrug substrate for tyrosine hydroxylase and thereby establish proof of concept for neuroblastoma directed enzyme prodrug therapy.
|
12880985 |
2003 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
New splicing variants for human Tyrosine Hydroxylase gene with possible implications for the detection of minimal residual disease in patients with neuroblastoma.
|
12493595 |
2003 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results indicate that GDNF up-regulates the expression of the TH gene by promoting the transcription of the TH gene and the stability of TH mRNA with the Ret receptor dependency in some neuroblastoma cell lines.
|
12358785 |
2002 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
LA-N-1 is a human neuroblastoma cell line expressing tyrosine hydroxylase.
|
12101048 |
2002 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mixtures of NB-1691 NB cells and CD34(+) hematopoietic cells purged by this method showed no evidence of viable tumor cells as assessed by clonogenic assays or reverse transcription-PCR for the NB cell markers tyrosine hydroxylase and N-MYC.
|
12208753 |
2002 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
L-DOPA and glia-conditioned medium have additive effects on tyrosine hydroxylase expression in human catecholamine-rich neuroblastoma NB69 cells.
|
11483656 |
2001 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells.
|
11769329 |
2001 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Also, after "purging," RNA for neuroblastoma cell markers (tyrosine hydroxylase, synaptophysin, and N-MYC) was undetectable by reverse transcription-PCR.
|
11431345 |
2001 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this prospective, multicenter study, the independent prognostic power of neuroblastoma cells detected by reverse transcriptase polymerase chain reaction (RT-PCR) for tyrosine hydroxylase (TH) mRNA was evaluated.
|
11251011 |
2001 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together our data indicate that MYCN may regulate TH expression in neuroblastoma cells, but not through binding to the 5' or 3' TH gene flanking sequences used in our experiments.
|
11018298 |
2000 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
As high expression of PGP 9.5 was only found in neural tumors; PGP 9.5 expression by ES provides further evidence for a neural origin of this tumor, whereas TH expression is highly specific for neuroblastomas.
|
10690538 |
2000 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of the neuroendocrine protein gene product 9.5 (PGP9.5) and tyrosine hydroxylase (TH) mRNA in BM and PB obtained from 18 patients with NB was investigated by reverse transcriptase-polymerase chain reaction (RT-PCR).
|
11051140 |
2000 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have used the rat tyrosine hydroxylase promotor to overexpress MYCN in the neural crest of transgenic mice, resulting in a mouse model for neuroblastoma.
|
10811128 |
2000 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH.
|
9578138 |
1998 |