|
Lung Neoplasms
|
0.800 |
CausalMutation
|
group |
CGI |
|
|
|
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Evaluation by chemical mismatch cleavage of eight p53 cDNAs derived from lung tumors shown to have different mutations by DNA sequencing correctly detected the presence of a point mutation in all instances.
|
2223098 |
1990 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Although this type of change cannot be detected immunohistochemically in primary tumors without further molecular analysis, the results presented herein indicate that p53 can be detected immunohistochemically in a majority of lung tumors and that there is a tendency for more advanced adenocarcinoma stages to exhibit positive p53 immunostain.
|
1656762 |
1991 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Alterations of p53 are one of the most common molecular changes found in all types of lung tumors, suggesting a crucial role for p53 in bronchial carcinogenesis.
|
8389245 |
1993 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Thus, this method provides a rapid and efficient approach for studying p53 mutations leading to an accumulated protein in lung tumors cells.
|
8317547 |
1993 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Several of the mutations found in SCC of the tongue (3/7) were in a region (codons 144-166) previously identified as being a p53 mutational hot spot in non-small cell lung tumours (Mitsudomi et al., 1992).
|
8390283 |
1993 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Squamous metaplasia in the close vicinity of surgically resected lung tumors were evaluated for their mitotic index and screened for proto-oncogenes and P 53 protein expression by immunohistochemistry and/or in situ hybridization.
|
8423673 |
1993 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Losses of heterozygosity on chromosome 11 were observed at several loci surrounding the p53 tumor-suppressor gene (Trp53) in 12 of 17 mammary tumors and 2 of 8 lung tumors.
|
8170984 |
1994 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
We have screened 108 non-small cell lung tumors for mutational alterations in the p53 gene (exons 5 through 8) using polymerase chain reaction and denaturing gel electrophoresis techniques.
|
8137262 |
1994 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
These results indicate that the p53-positive immunophenotype uncovers the occurrence of p53 point mutations in lung cancer and that p53 and c-myc gene alterations are important but represent independent occurrences in the development of lung tumors.
|
8014012 |
1994 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
The results in Salmonella are consistent with a role for the PAH component of cigarette smoke in the base-substitution specificity found in the p53 gene of smoking-associated lung tumors.
|
7586163 |
1995 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
In two cases, the lung tumors exhibited a p53 mutation not present in the previously removed primary tumor and were therefore classified as new primary lung cancers.
|
8614143 |
1996 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry for p53 on AC lung tumors may be helpful to delineate cases at higher risk for aggressive behavior.
|
8623922 |
1996 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
To test this hypothesis in lung tumours, 43 lung carcinomas were analysed by in situ hybridisation and polymerase chain reaction (PCR) for the presence of HPV DNA, and the results were compared with p53 protein immunohistochemical analysis.
|
8984698 |
1996 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
The results of this investigation indicate that alterations in the K-ras and p53 pathways do not play a major role in the genesis of X-ray-induced lung tumors in the rat.
|
8600505 |
1996 |
|
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance.
|
8630278 |
1996 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Four tissue specimens of lung tumors with mutations in exon 7 of the p53 gene were found to have mutant alleles; six-base-pair deletion at codons 247-248, a one-base-pair deletion at codon 260, a one-base-pair deletion at codon 244 and a GGC to CGC substitution at codon 244.
|
8843680 |
1996 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
The p53 mutational profile of SCCHN tumors was similar to that of non-small cell lung tumors from patients within the same geographical area, supporting the idea of a common model for carcinogenesis in the upper respiratory tract.
|
9307295 |
1997 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Inactivation of the tumour-suppressor gene p53 has been described as one of the most common molecular changes found in lung tumours.
|
9218731 |
1997 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus.
|
9662254 |
1998 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
We analyzed 37 AAHs and their paired overt lung neoplasms for p53 protein accumulation using the monoclonal antibody DO7.
|
9712420 |
1998 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Using data from the the International Agency for Research on Cancer p53 mutation database (R1), we have analyzed the distribution and nature of p53 mutations in 876 lung tumors described in the literature.
|
9637795 |
1998 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
In conclusion, evaluation of mutations of both the p53 and K-ras genes in the lung tumors might be useful for assessing the prognosis, especially in patients with adenocarcinoma.
|
9472092 |
1998 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Three different patterns in the distribution of p53 mutations in double lung tumours were observed: [A] mutation in only one of the tumours (four cases), [B] different mutations in the tumours (two cases), and [C] same mutation in both tumours (one case).
|
10188905 |
1999 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
The mean in vitro bleomycin-induced breaks per cell (a marker of cancer susceptibility) was significantly higher (0.92) for patients who overexpressed p53 in lung tumour tissue than that for patients with no detectable p53 expression in lung tumour tissue (0.65).
|
10408853 |
1999 |