|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age.
|
31527889 |
2019 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We compared distributions of PNPLA3 genotypes in 80 and 81 Caucasian patients with alcoholic and hepatitis C virus (HCV)-associated HCC to 80 and 81 age- and sex-matched patients with alcohol-related and HCV-related cirrhosis without HCC, respectively.
|
22087248 |
2011 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3 GG genotype was significantly associated with underlying cirrhosis in HCC patients (OR = 2.48; 95% CI, 1.05-5.87).
|
23776098 |
2013 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Correction: Genetic Variants in PNPLA3 and TM6SF2 Predispose to the Development of Hepatocellular Carcinoma in Individuals With Alcohol-Related Cirrhosis.
|
29895985 |
2018 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Second, although the strongest genetic risk alleles for NAFLD (ie, the 148Met allele in PNPLA3 and the 167Lys allele in TM6SF2) are associated with increased liver fat content and progression to NASH and cirrhosis, these alleles are also unexpectedly associated with an apparent protection from cardiovascular disease.
|
30174213 |
2019 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Homozygous carriers of the PNPLA3 variant are prone to develop cirrhosis in the absence of other risk factors such as alcohol or viral hepatitis.
|
24222094 |
2013 |
|
Cirrhosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The familiality and hereditability of alcohol-related cirrhosis is not as well-documented but three strong candidate genes PNPLA3, TM6SF2 and MBOAT7, have been identified.
|
27575312 |
2017 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In ALD&NAFLD patients, the PNPLA3 148M allele was associated with younger age, shorter history of cirrhosis, less advanced (Child A) cirrhosis at HCC diagnosis, and lower HCC differentiation grade (p<0.05).
|
24155878 |
2013 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis pooled four studies with 1135 cases of chronic hepatitis B (CHB) to evaluate the impact of PNPLA3 SNP on liver steatosis and also pooled five studies with 3713 cases of CHB to evaluate the impact of PNPLA3 SNP on cirrhosis.
|
29218813 |
2018 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The -1195GG genotype of single nucleotide polymorphism (SNP) in COX-2 promoter was associated with low platelet counts in patients with chronic hepatitis C. Polymorphism of patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene (rs738409 C>G) have been reported to be associated with cirrhosis, and the major genotype of SNPs near interleukin (IL)28B are related to viral clearance.
|
22863264 |
2012 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 genotypes were also associated with higher risk of developing liver fibrosis and cirrhosis in dominant (aOR: 1.98, P=2.20*10-5; aOR: 1.67, P=0.008, respectively) and recessive (aOR: 3.94, P=5.16*10-5; aOR: 3.02, P=0.003, respectively) models.
|
28338112 |
2017 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriage of rs738409:G in PNPLA3 is associated with an increased risk of developing alcohol-related cirrhosis and has a significant negative effect on survival.
|
28161471 |
2017 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs738409 (rs738409" genes_norm="80339">I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis.
|
25378656 |
2015 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3 Genetic Variant rs738409 Influences the Progression to Cirrhosis in HIV/Hepatitis C Virus Coinfected Patients.
|
27973562 |
2016 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Whether the PNPLA3 rs738409 polymorphism could be a risk factor for the development of hepatocellular carcinoma (HCC) in cirrhosis patients is unknown.
|
21745286 |
2011 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of note, the PNPLA3 risk variant advances fibrosis in the total cohort as well as in the subgroups of patients with viral hepatitis and non-viral liver diseases and contributes 16% of the total cirrhosis risk.
|
21168459 |
2011 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TM6SF2 C/T or T/T in conjunction with PNPLA3 G/G variants may be potential genetic risk factors for developing HCC in alcohol-related cirrhosis.
|
26493626 |
2016 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prdevious meta-analyses assess whether or not patatin-like phospholipase domain containing 3 (PNPLA3) (rs738409 C > G) was associated with increased risk of hepatocellular carcinoma (HCC) in Caucasians patients with hepatitis C virus (HCV)-related cirrhosis, these meta-analyses did not provide firm conclusions.
|
29089161 |
2018 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3 CG/GG SNP at rs738409 was significantly associated with the presence of cirrhosis (odds ratio [OR], 1.76; 95% confidence interval [CI], 1.34-2.30), after adjusting for age, sex, diabetes, and race.
|
26305067 |
2016 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The population attributable risk of cirrhosis in alcoholic carriers of allele PNPLA3 rs738409(G) was estimated at 26.6%.
|
21254164 |
2011 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development.
|
24114809 |
2014 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among 270 HBV-infected patients, concurrent fatty liver was found in 107 patients (39.6%) and was associated with metabolic risks, cirrhosis (P = 0.016) and PNPLA3 rs738409 CG/GG genotype (P = 0.002).
|
27547913 |
2017 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis.
|
29535416 |
2018 |
|
Cirrhosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.
|
21334404 |
2011 |