|
rs700519
|
CYP19A1;MIR4713HG
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
In addition, a stratified analysis by menopausal status indicated that the association of the CYP19 polymorphisms (rs10046 and rs700519) with BC risk was mainly evident in premenopausal women, and the association of CYP19 rs700519 with BC risk was significant in women less than 50 years old.
|
27323034 |
2016 |
|
rs700519
|
CYP19A1;MIR4713HG
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
Our findings suggest that rs700519 and rs2069522 are associated with susceptibility to breast cancer among the Han Chinese population and have a cumulative effect with three other identified SNPs.
|
25689428 |
2015 |
|
rs700519
|
CYP19A1;MIR4713HG
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
We examined the association of single nucleotide polymorphism (SNP) in estrogen receptors, ESR1 (rs2234693) and ESR2 (rs2987983); estrogen biosynthesis enzymes, CYP17A1 (rs743572); and aromatase, CYP19A1 (rs700519) with breast cancer risk.
|
24430361 |
2014 |
|
rs700519
|
CYP19A1;MIR4713HG
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
A DNA bank of patients with gynecologic oncology, patients with breast cancer (n = 335), and healthy women (n = 530) was created, and the following single-nucleotide polymorphisms were examined: CYP1A1 M1 polymorphism, that is, T264-C transition in the 30-noncoding region; CYP1A2*1F polymorphism, that is, C734-A transversion in the CYP1A2 gene; C-T transition (Arg264Cys) in exon 7 of CYP19; and SULT1A1*2 polymorphism, that is, G638-A transition (Arg213His) in the SULT1A1 gene.
|
21977969 |
2012 |
|
rs700519
|
CYP19A1;MIR4713HG
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
A total of 22 studies with 10,592 cases and 11,720 controls were identified, and the results showed that R264C polymorphism was not associated with breast cancer risk in overall (T vs. C: OR = 1.061, 95% CI = 0.929-1.212) or race-based populations (T vs. C for Asian: OR = 1.169, 95% CI = 1.002-1.363; for Caucasian: OR = 0.787, 95% CI = 0.597-1.037); meanwhile, for Asian individuals, 3-bpDel/Ins polymorphism showed a significantly association with breast cancer susceptibility (for allele Del vs. allele Ins: OR = 1.278, 95% CI = 1.066-1.532) while the carriers of allele (TTTA)(12) can significantly decrease breast cancer risk (OR = 0.752, 95% CI = 0.603-0.939).
|
20052540 |
2010 |
|
rs700519
|
CYP19A1;MIR4713HG
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
The nonsynonymous SNP, rs700519 (Arg264Cys), located in haplotype block 4, was also associated with breast cancer survival.
|
17119036 |
2006 |
|
rs700519
|
CYP19A1;MIR4713HG
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer</span> risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.
|
12618873 |
2003 |