|
rs41508050
|
HIF1A;HIF1A-AS3
|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation |
BEFREE |
Three polymorphisms in HIF1A (Pro582Ser, rs11549465; rs1087314; and Thr418Ile, rs41508050) were significantly more common in patients who presented with stable exertional angina rather than acute MI, even after statistical adjustment for cardiac risk factors and medications.
|
18035072 |
2007 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype distribution of rs1061170 (CFH), rs429608 (SKIV2L), rs2679798 (MYRIP) and both rs11549465 and rs11549467 (HIF1A) in AMD cases and healthy controls; association between genotypes and AMD subtypes.
|
24995509 |
2015 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype distribution of rs1061170 (CFH), rs429608 (SKIV2L), rs2679798 (MYRIP) and both rs11549465 and rs11549467 (HIF1A) in AMD cases and healthy controls; association between genotypes and AMD subtypes.
|
24995509 |
2015 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
androgen independent prostate cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
However, we found that, among men with the homozygous CC wild-type (but not CT/TT) of the HIF-1alpha P582S, higher IGFBP-3 levels (>/= vs. <median) were associated with a 28% (95% CI, 0.55-0.95; P(interaction) = 0.01) lower risk of overall CaP and a 53% (0.25-0.88; P(interaction) = 0.11) lower risk of metastatic and fatal CaP.
|
17624927 |
2007 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
androgen independent prostate cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither the P582S nor the A588T polymorphism was associated with risk of overall or metastatic/fatal CaP.
|
17624927 |
2007 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Anemia
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings show for the first time that the HIF-1α(Pro-582-Ser) polymorphism significantly affects red blood cell and iron homeostasis after blood loss, conferring to male carriers a resistance to anaemia.
|
24120591 |
2013 |
|
rs1430452530
|
HIF1A;HIF1A-AS3
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a well-defined, autochthonous Kras(G12D)-driven murine model, as well as human tumors, we demonstrate that hypoxia and stabilization of hypoxia-inducible factor 1α (HIF1α), a principal mediator of hypoxic adaptation, emerge early during preinvasive stages of PDAC.
|
26715642 |
2016 |
|
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the rs2057482-CC genotype increases the susceptibility to PDAC and associated with cancer progression.
|
26872370 |
2016 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings support the hypothesis that the HIF-1Alpha P582S variant may confer susceptibility to subgroups of breast cancer in Korean women.
|
18160046 |
2008 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest the potential use of C1772T (P582S) polymorphism and expression analysis in providing a new prognostic factor for unfavorable disease outcomes and may help for clinical decision-making in the treatment of breast cancer patients.
|
18949419 |
2008 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results indicated a boardline connection between HIF-1 rs11549467 and BC risk (AG compared with GG: OR = 1.61, 95% CI = 1.05-2.49, <i>P</i>=0.03; AG + AA compared with GG: OR = 1.64, 95% CI = 1.08-2.51, <i>P</i>=0.02; AG compared with GG + AA: OR = 1.61, 95% CI = 1.04-2.48, <i>P</i>=0.03; OR = 1.64, 95% CI = 1.09-2.45, <i>P</i>=0.02), while HIF-2 rs17039192 had no influence on breast cancer.
|
30135144 |
2018 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
There were no significant differences in genotypic frequencies for P582S and A588T between breast cancer patients and controls, nor between the transcriptional activity of the 582S mutant and the wild-type HIF-1α.
|
23749907 |
2013 |
|
rs142179458
|
HIF1A;HIF1A-AS3
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Subtype analysis performed for patient subgroups defined by ER, PR, and HER2 status suggested additional associations of the <i>NOTCH3</i> SNP rs200504060 and the <i>HIF1A</i> SNP rs142179458 with breast cancer risk.
|
28775167 |
2017 |
|
rs574603732
|
HIF1A;HIF1A-AS3
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
HSP90α Gln488His polymorphism seems to be a risk factor for breast cancer.
|
23065205 |
2012 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Cancer of Digestive System
|
|
0.010 |
GeneticVariation |
BEFREE |
HIF-1α P582S and A588T polymorphisms and digestive system cancer risk-a meta-analysis.
|
24293391 |
2014 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Cancer of Digestive System
|
|
0.010 |
GeneticVariation |
BEFREE |
HIF-1α P582S and A588T polymorphisms and digestive system cancer risk-a meta-analysis.
|
24293391 |
2014 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Carcinogenesis
|
|
0.010 |
GeneticVariation |
BEFREE |
Hypoxia-inducible factor-1 alpha (HIF-1α) P582S polymorphism has been reported to increase transactivation capacity of HIF-1α, which is prone to tumorigenesis.
|
25337255 |
2014 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation |
BEFREE |
When stratified by study design, significantly elevated susceptibility to cancer was found among hospital-based studies.These findings suggested that the 1790G/A (rs11549467) genetic polymorphism may contribute to the susceptibility of cancers except gynecologic cancer, especially in homozygote comparison and recessive genetic model among Caucasian population, and this SNP was significantly associated with the lung cancer, pancreatic cancer and oral squamous cell carcinoma (OSCC).
|
24824937 |
2014 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation |
BEFREE |
In this study, we have investigated the relationship between seven HIF-1alphapolymorphisms [C > T substitution in intron 8 (rs10873142), T418I (rs41508050) in exon 10, P564P (rs41492849), L580L (rs34005929), P582S (rs11549465), A588T (rs11549467) in exon 12 and dinucleotide GT repeats in intron 13 (rs10645014)] among lung cancer patients in the Turkish population.
|
19546348 |
2009 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation |
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
cervical cancer
|
|
0.020 |
GeneticVariation |
BEFREE |
In a case-control study of 518 cervical cancer patients and 553 cancer-free controls, we genotyped three single-nucleotide polymorphisms (SNPs) (rs11549465, rs11549467 and rs2057482) of HIF-1α using the TaqMan SNP Genotyping Assays and assessed its associations with the cervical cancer risk.
|
24195510 |
2014 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
cervical cancer
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that HIF-1α P582S polymorphism may be associated with the risk of cervical cancer.
|
25337255 |
2014 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
cervical cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
In a case-control study of 518 cervical cancer patients and 553 cancer-free controls, we genotyped three single-nucleotide polymorphisms (SNPs) (rs11549465, rs11549467 and rs2057482) of HIF-1α using the TaqMan SNP Genotyping Assays and assessed its associations with the cervical cancer risk.
|
24195510 |
2014 |