APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Impaired glucose tolerance ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs781049584
rs781049584
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0271650
Disease:
Impaired glucose tolerance 		0.010 GeneticVariation BEFREE We therefore investigated the susceptibility of transgenic mice carrying human mutated transgenes for amyloid precursor protein (APP (SWE)) and presenilin 1 (PSEN1 (A246E)) (APP/PSEN1), or PSEN1 (A246E) alone, which are well-characterised animal models of Alzheimer's disease, to develop obesity, glucose intolerance and insulin resistance, and whether this was age- and/or diet-dependent. 21538175 2011