rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure.
|
31446980 |
2019 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data demonstrated that the SNPs rs25487 and rs1052133</span> are risk factors for lung cancer in epidemiologically susceptible Chinese people.
|
26634519 |
2015 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Despite some limitations, this meta-analysis provides solid evidence that hOGG1 Ser326Cys polymorphism may contribute to lung cancer risk, particularly for Asian populations, never smokers, and more-cigarette takers.
|
24085357 |
2014 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The combined results suggested that the hOGG1 Ser326Cys polymorphism was not associated with lung cancer susceptibility in different genetic models.
|
24435978 |
2014 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we investigated the polymorphisms of following selected DNA repair genes: XPC (Lys939Gln), XPD (Lys751Gln), hOGG1 (Ser326Cys) and XRCC1 (Arg399Gln), and the risks they present towards the development of lung cancer with the emphasis to gender differences within the Slovak population.
|
23673479 |
2013 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data showed that the hOGG1 Ser326Cys polymorphism contributed to the risk of lung cancer.
|
23971971 |
2013 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
We demonstrated a novel, significant correlation between the hOGG1 Ser326Cys polymorphism and increased lung cancer susceptibility in Caucasians.
|
22855704 |
2012 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
For example, there was a positive association between the OGG1 Ser326Cys variant and gastric and lung cancer, while the XRCC1 Arg399Gln variant was associated with reduced cancer risk.
|
23023028 |
2012 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The hOGG1 Ser326Cys polymorphism is associated with lung cancer risk, but there are limited data regarding an association between the APE1 Asp148Glu polymorphism and lung cancer.
|
23038158 |
2012 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
In a nested case-cohort design we examined associations between urinary excretion of 8-oxoGua and risk of lung cancer as well as potential interaction with the OGG1 Ser326Cys polymorphism in a population-based cohort of 25,717 men and 27,972 women aged 50-64 years with 3-7 years follow-up.
|
22044660 |
2012 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched publications from MEDLINE and EMBASE which were assessing the associations between OGG1 Ser326Cys polymorphism and lung cancer risk.
|
22540013 |
2012 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a study with the larger sample size is needed to further evaluated gene-environment interaction on OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and lung cancer risk.
|
23065211 |
2012 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, in subgroup analyses by cancer types, the stronger significant association between hOGG1 Ser326Cys polymorphism and lung cancer risk was found (Cys/Cys vs. Ser/Ser: OR = 1.29, 95%CI = 1.16-1.44, P<0.001; Cys/Cys vs. Cys/Ser+Ser/Ser: OR = 1.22, 95%CI = 1.12-1.33, P<0.001).
|
22114677 |
2011 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
In a hospital-based, case-control study of 455 lung cancer cases and 443 cancer-free hospital controls, the SNPs of OGG1 (Ser326Cys), XRCC1 (Arg399Gln), APE1 (Asp148Glu and -141T/G) were genotyped and analyzed for their correlation with the risk of lung cancer in multivariate logistic regression models.
|
21722819 |
2011 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, the hOGG1 Ser326Cys polymorphisms were associated with the risk of lung cancer.
|
21790253 |
2011 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Although several studies have investigated the association between rs1052133 and lung cancer susceptibility, the effect of this locus on lung cancer according to histology remains unclear.
|
19881468 |
2009 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphic frequency of 10 genetic susceptibility genes and their association with lung cancer were examined in a northern Thai population: CYP1A1 (MspI), CYP1A1 (Ile462Val), CYP2E1 (PstI), CYP2E1 (DraI), GSTM1, GSTT1, MPO (AciI), OGG1 (Ser326Cys), TP53 (Arg72Pro), and MMP1(AluI).
|
19963114 |
2009 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The effect of tobacco exposure and the OGG1 Ser326Cys showed also no significant risk for lung cancer.
|
19161591 |
2009 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study.
|
18155253 |
2008 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The hOGG1 Ser326Cys polymorphism and lung cancer risk: a meta-analysis.
|
18628426 |
2008 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
OGG1 S326C homozygote was suggested to be associated with lung cancer risk in Caucasians (homozygote OR, 1.34; 95% CI, 1.01-1.79) based on 2,569 cases and 4,178 controls from 4 studies but not in Asians.
|
18990748 |
2008 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Both the XRCC1 Arg194Trp and Arg280His as well as the OGG1 Ser326Cys heterozygous genotypes were associated with a significantly reduced risk for lung cancer (OR=0.32, p=0.024; OR=0.25, p=0.028; OR=0.51, p=0.033, respectively).
|
17531525 |
2007 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Case-control studies of genetic polymorphisms in DNA repair enzymes suggest that the common variant Ser326Cys in OGG1 may be a risk factor for lung cancer, whereas a rare variant in OGG1 and germ line mutations in the corresponding mismatch repair gene MYH are risk factors for hereditary colon cancer.
|
16771692 |
2007 |
rs1052133
|
OGG1;CAMK1
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
There was a statistically significant interaction between the polymorphism and dietary intake of vegetables, with a 54% decrease in lung cancer risk per 50% increase in vegetable intake among homozygous Cys326Cys carriers and no decrease in risk among carriers of Ser326Ser or Ser326Cys.
|
17015267 |
2006 |