|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant associations were found with binary obesity status for rs6232 (OR = 1.15, 95% CI 1.06-1.24, P = 6.08 × 10(-6)) and rs6234/rs6235 (OR = 1.07, 95% CI 1.04-1.10, P = 3.00 × 10(-7)).
|
25784503 |
2015 |
|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, PCSK1 rs6235 risk allele was related to Adv36 seropositivity (chi(2)=6.85, p=0.033) in overweight/obese subgroup.
|
26680480 |
2015 |
|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data revealed no association of PCSK1 rs6235 with the risk of obesity or overweight in the complete subjects.
|
24140494 |
2014 |
|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
No difference was found in the association with different obesity grades, and no association of PCSK1 rs6234-rs6235</span> with obesity was identified in Asian populations.
|
25355447 |
2014 |
|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
These results indicate that common PCSK1 variants (notably rs6232 and rs6235) contribute modestly to obesity in multi-ethnic American population.
|
23451278 |
2013 |
|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the association of the PCSK1 single-nucleotide polymorphism (SNP) rs6235 (encoding an S690T substitution) with essential hypertension (EH), obesity and related traits in the Han Chinese population.
|
22592666 |
2012 |
|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group.
|
22737226 |
2012 |
|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity.
|
20534142 |
2010 |
|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our data suggest that the PCSK1 rs6232 and rs6235 SNPs are not major contributors to common obesity in the general population.
|
19528091 |
2009 |
|
rs6235
|
PCSK1;LOC101929710
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
The nonsynonymous variants rs6232, encoding N221D, and rs6234-rs6235, encoding the Q665E-S690T pair, were consistently associated with obesity in adults and children (P = 7.27 x 10(-8) and P = 2.31 x 10(-12), respectively).
|
18604207 |
2008 |