rs121913529, KRAS

N. diseases: 144
Disease: Brain Neoplasms ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Brain Neoplasms
CUI: C0006118
Disease: Brain Neoplasms
0.030 GeneticVariation BEFREE Further, one of the patients (c.35G>A; p.(Gly12Asp)) had a myeloproliferative disorder, and one subject (c.34G>C; p.(Gly12Arg)) exhibited an uncharacterized brain tumour. 28594414 2017
Brain Neoplasms
CUI: C0006118
Disease: Brain Neoplasms
0.030 GeneticVariation BEFREE When expressed under the control of the krt5 gene promoter, KRAS(G12V) induced bra</span>in tumors in ventricular zones (VZ) at low frequency. 25644510 2015
Brain Neoplasms
CUI: C0006118
Disease: Brain Neoplasms
0.030 GeneticVariation BEFREE PKM2-regulated MLC2 phosphorylation, which is greatly enhanced by EGF stimulation or EGFRvIII, K-Ras G12V and B-Raf V600E mutant expression, plays a pivotal role in cytokinesis, cell proliferation and brain tumour development. 25412762 2014