Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
5,10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T and A1298C, have been reported to be associated with decreased risk of acute lymphoblastic leukemia (ALL).
|
22943282 |
2012 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was carried out.
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16897583 |
2006 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although no consistent results on associations between MTHFR A 1298C polymorphism and ALL in the populations studied were obtained, the A1298C polymorphism, at least in Koreans, may be a genetic determinant among childhood ALL patients.
|
16886608 |
2006 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA samples taken from patients with ALL and controls were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays to detect the MTHFR C677T and A1298C mutations.
|
17970089 |
2007 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
For the MTHFR A1298C polymorphism, no significant association with ALL susceptibility was observed in the pooled analyses.
|
21702646 |
2011 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, 677T allele was linked to a decrease risk of ALL [odds ratio (OR), 0.43; 95% confidence interval (CI), 0.22-0.86], whereas the 1298A>C polymorphism presents an elevated risk factor [OR, 2.01; 95% CI, 1.01-3.99] in non-White children.
|
16182363 |
2006 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a significant association was detected between the MTHFR A1298C/ RFC G80A genotype and a nonpredisposition for ALL (P = 0.035).
|
24237708 |
2014 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a case-control study of 203 patients with ALL and 246 controls and meta-analysis in the Indian population, we showed an insignificant association of MTHFR C677T and A1298C genotypes with childhood and adult ALL.
|
25115513 |
2015 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, MTHFR, C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity in pediatric ALL.
|
23089671 |
2013 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the MTHFR C677T and A1298C haplotypes might be useful for monitoring adverse effects in childhood ALL maintenance therapy in Japanese patients.
|
23865834 |
2014 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In total, 167 children with ALL were genotyped for methylenetetrahydrofolate dehydrogenase (MTHFD1) 1958G > A, methylenetetrahydrofolate reductase (MTHFR) 677C > T and 1298A > C and thymidylate synthase (TYMS) 2R > 3R polymorphisms.
|
22074251 |
2012 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL).
|
20374270 |
2010 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Most studies found a strong association between the polymorphisms MTHFR, C677T or A1298C, and NQO1*2 or *3 and the risk of acute lymphoblastic leukemia (ALL).
|
17023046 |
2006 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association between the A1298C variant and susceptibility to both adult and childhood ALL was disclosed.
|
17035405 |
2006 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant relation was found between MTHFR A1298C polymorphism and the risks of therapy induced complications or relapse rate in the studied ALL patients.
|
19923983 |
2010 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that MTHFR C677T and A1298C polymorphisms are unlikely to affect the development of childhood ALL in an Egyptian population from Delta.
|
25629981 |
2015 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the MTHFR 677C>T and 1298A>C gene variants do not have a major influence on the susceptibility to pediatric ALL in the German population.
|
15921520 |
2005 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the MTHFR C677T and A1298C polymorphisms may be potential biomarkers for ALL risk in Chinese populations, and studies with a larger sample size and wider population spectrum are required before definitive conclusions can be drawn.
|
25342508 |
2014 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Seventy-two children with ALL and 109 age- and sex-matched healthy children from Western Iran were screened for MTHFR C677T and A1298C variants by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
|
22017305 |
2012 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The A1298C polymorphism had an effect on ALL risk neither in adults (Dominant model: OR(FE)=0.95, 95% CI: 0.71-1.27, p=0.72) nor in children (Dominant model: OR(FE)=1.02, 95% CI: 0.87-1.21, p=0.77).
|
23061880 |
2012 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the influence of C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene on MTX-induced toxicity during treatment of children with ALL.
|
26528799 |
2015 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aims of this study were to (a) to determine the prevalence of seven common genetic polymorphisms including those that affect the folate and/or thiopurine metabolic pathways, i.e. cyclin D1 (CCND1-G870A), γ-glutamyl hydrolase (GGH-C452T), methylenetetrahydrofolate reductase (MTHFR-C677T and MTHFR-A1298C), thymidylate synthase promoter (TYMS-TSER), thiopurine methyltransferase (TPMT*3A and TPMT*3C) and inosine triphosphate pyrophosphatase (ITPA-C94A), in Caucasian (n = 94, age < 20) and Vietnamese (n = 141, age < 16 years) childhood ALL and (b) to assess the impact of a multilocus genetic risk score (MGRS) on relapse-free survival (RFS) using a Cox proportional-hazards regression model.
|
25099492 |
2015 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic association studies (GAS) that investigated the association between ALL and the MTHFR C677T and A1298C gene variants have produced contradictory or inconclusive results.
|
22094326 |
2012 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal.
|
16096524 |
2005 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014).
|
29390492 |
2017 |