rs429358, APOE

N. diseases: 66
Disease: Dementia ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Dementia
CUI: C0497327
Disease: Dementia
0.030 GeneticVariation BEFREE There was no interaction between rs9331896 in CLU and rs429358 (defining the ɛ4 allele) in APOE in predicting Alzheimer's disease or all dementia (P = 0.39 and P = 0.21). 29534716 2018
Dementia
CUI: C0497327
Disease: Dementia
0.030 GeneticVariation BEFREE When adjusted for CSF Aß42, the association of rs429358 with de</span>mentia</span> is greatly reduced but remains significant indicating that APOE polymorphism influences disease by additional mechanisms distinct from Aß42 metabolism. 20847432 2010
Dementia
CUI: C0497327
Disease: Dementia
0.030 GeneticVariation BEFREE The apo E4 (Arg112-Cys) polymorphism has been associated with dementia and hypercholesterolemia. 11257253 2001