rs5848, FAM171A2;GRN

N. diseases: 17
Disease: Pick Disease of the Brain ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Pick Disease of the Brain
CUI: C0236642
Disease: Pick Disease of the Brain
0.020 GeneticVariation BEFREE The GRN risk SNP (rs5848_T) was associated with a pattern of atrophy in the dorsomedial frontal lobes bilaterally, remarkable since GRN is a risk factor for frontotemporal dementia. 27003218 2016
Pick Disease of the Brain
CUI: C0236642
Disease: Pick Disease of the Brain
0.020 GeneticVariation BEFREE In support of these findings, the neuropathology of homozygous rs5848 T-allele carriers frequently resembled the pathological FTLD-U subtype of GRN mutation carriers. 18723524 2008