Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.
The genotypes rs6733839 in the <i>BIN1</i> gene and rs28834970 in the <i>PTK2B</i> gene approached significance in the PENN cohort and were significantly associated with reduced AD risk in the NACC cohort.
Altogether, five loci (rs6656401 at CR1, rs983392within MS4A6A, rs11218343 at SORL1, rs6733839 at BIN1, and APOE ε4) have been detected to be associated with one or a few established AD-related neuroimaging measures.